| Long name: |
ALEXA FLUOR 488 Conjugated, Dab1 (Ser524) Polyclonal Antibody |
| Also known as: |
Anti-Dab1 Ser524 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Dab1 Ser524 |
| Specificity: |
This is a highly specific antibody against Dab1 Ser524 |
| Modification: |
Phosphorylation |
| Modification Site: |
Ser524 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human Dab1 around the phosphorylation site of Ser524 |
| Gene ID Number: |
1600 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Dab1 also mediates activation of Akt (PKB) by reelin resulting in inhibition of glycogen synthase kinase 3 beta (GSK-3 beta) and decreased phosphorylation of the microtubule-associated protein, Dab1 contains a phosphotyrosine binding (PTB) domain in the amino terminus, Dab1 is an intracellular adapter protein that functions in downstream signaling events initiated by the secreted protein reelin, Dab1 serine 491 is phosphorylated in a Cdk5-dependent manner and regulates, Phenotypically, Reelin-induced signaling during neural cortex development, Src family kinase and c-Abl activities are themselves then stimulated by binding to tyrosine phosphorylated Dab1, Tau, Tyrosine phosphorylation of Dab1 is increased by reelin binding to the Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) through stimulation of Src family kinases, and severe cerebellar hypoplasia, disruption of neuronal migration, likely indirectly, the mutation of this gene produces motor defects and ataxia, Disabled 1 (Dab1) is an 80 kDa protein that is encoded by the Disabled-1 gene locus which is mutated in scrambler and yotari mutant mice |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
Disabled homolog 1, Disabled homolog 1 Drosophila, Scm, Scr, Scrambler, Yot, Yotari, Dab 1 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Dab1 (Ser524) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Dab1 (Ser524) |
| Short name: |
Dab1 (Ser524) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, disabled homolog 1 (Drosophila) (Ser524) (Antibody to) |
| Alternative technique: |
antibodies |