| Long name: |
Aurora A (Thr288) Primary Polyclonal Antibody |
| Also known as: |
Aurora A (Thr288) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Aurora A Thr288 |
| Specificity: |
This antibody may detect this protein in mouse when phosphorylated at Thr279, This phosphorylation site is homologous to that of Thr281 in Rat, but at a reduced affinity due to a single amino acid change in the immunogen, This is a highly specific antibody against Aurora A Thr288 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Thr288 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
260-300/403 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human Aurora A around the phosphorylation site of Thr288 |
| Gene ID number: |
6790 |
| Swiss Prot: |
O14965 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Also acts as a key regulatory component of the p53/TP53 pathway, Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, BORA, BRCA1, CDC25B, DLGP5, HDAC6, Important for microtubule formation and/or stabilization, KIF2A, LATS2, NDEL1, Necessary for proper cilia disassembly prior to mitosis, PARD3, PLK1, PPP1R2, Phosphorylates its own inhibitors, Phosphorylates numerous target proteins, Plays a role in microtubule remodeling during neurite extension, RASSF1, Regulates KIF2A tubulin depolymerase activity, Required for initial activation of CDK1 at centrosomes, Required for normal axon formation, TACC3, and cytokinesis, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, including ARHGEF2, p53/TP53 and TPX2, spindle assembly checkpoint, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity, Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
AIRK1, ARK-1, ARK1, AURA, AURKA, AURORA2, AYK1, Aurora 2, Aurora kinase A, Aurora-related kinase 1, Aurora/IPL1-related kinase 1, BTAK, Breast tumor-amplified kinase, IAK1, PPP1R47, STK15, STK6, STK7, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A, hARK1, AIK |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Aurora A (Thr288) |
| Short name: |
Aurora A (Thr288) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Aurora A (Thr288) (Antibody to) |
| Alternative technique: |
antibodies |