| Long name: |
ALEXA FLUOR 555 Conjugated, Ack1 (Tyr284) Polyclonal Antibody |
| Also known as: |
Anti-Ack1 Tyr284 PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Ack1 Tyr284 |
| Specificity: |
This is a highly specific antibody against Ack1 Tyr284 |
| Modification: |
Phosphorylation |
| Modification Site: |
Tyr284 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
260-310/1055 |
| Subcellular location: |
Membrane bound, Nucleus |
| Source: |
KLH conjugated synthetic phosphopeptide derived from mouse Ack1 around the phosphorylation site of Tyr284 |
| Gene ID Number: |
51789 |
| Swiss Prot: |
O54967 |
| Tested applications: |
IF(IHC-P), FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
AR, Activates AKT1 by phosphorylating it on 'Tyr-176', Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR, Contributes to the control of AXL receptor levels, Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1, Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin, MCF2, May be involved both in adult synaptic function and plasticity and in brain development, Phosphorylates AKT1, Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs), Phosphorylates MCF2, Phosphorylates WWOX on 'Tyr-287', Transduces extracellular signals to cytosolic and nuclear effectors, WASL and WWOX, cell growth and proliferation, cell survival, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins, Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
Ack-1, Ack1, Activated CDC42 kinase 1, Cdgip, Non-receptor protein tyrosine kinase Ack, Pyk1, Tnk2, Tyrosine kinase non-receptor protein 2, Ack |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
Ack1 (Tyr284) |
| Short name: |
Ack1 (Tyr284) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, Ack1 (Tyr284) (Antibody to) |
| Alternative technique: |
antibodies |