Ack1 (Tyr284) Antibody, ALEXA FLUOR 488

Catalog number:	bs-3045R-A488 Buy Now
Price:	263 €
Supplier:	Bioss Primary Unconjugated Antibodies
Product name:	Ack1 (Tyr284) Antibody, ALEXA FLUOR 488
Quantity:	0.1ml
Related search:	tyr ack alexa antibody fluor antibodies conjugated kinase protein cdc

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Long name:	ALEXA FLUOR 488 Conjugated, Ack1 (Tyr284) Polyclonal Antibody
Also known as:	Anti-Ack1 Tyr284 PAb ALEXA FLUOR 488
Category:	Conjugated Primary Antibodies
Conjugated with:	488, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	Ack1 Tyr284
Specificity:	This is a highly specific antibody against Ack1 Tyr284
Modification:	Phosphorylation
Modification Site:	Tyr284
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	260-310/1055
Subcellular location:	Membrane bound, Nucleus
Source:	KLH conjugated synthetic phosphopeptide derived from mouse Ack1 around the phosphorylation site of Tyr284
Gene ID Number:	51789
Swiss Prot:	O54967
Tested applications:	IF(IHC-P), FCM
Recommended dilutions:	IF(IHC-P)(1:50-200), FCM(1:20-100)
Crossreactivity:	Mouse, Rat, Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	AR, Activates AKT1 by phosphorylating it on 'Tyr-176', Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR, Contributes to the control of AXL receptor levels, Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1, Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin, MCF2, May be involved both in adult synaptic function and plasticity and in brain development, Phosphorylates AKT1, Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs), Phosphorylates MCF2, Phosphorylates WWOX on 'Tyr-287', Transduces extracellular signals to cytosolic and nuclear effectors, WASL and WWOX, cell growth and proliferation, cell survival, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins, Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	499nm/519nm
Synonyms:	Ack-1, Ack1, Activated CDC42 kinase 1, Cdgip, Non-receptor protein tyrosine kinase Ack, Pyk1, Tnk2, Tyrosine kinase non-receptor protein 2, Ack
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Ack1 (Tyr284) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	Alexa Fluor
Gene target:	Ack1 (Tyr284)
Short name:	Ack1 (Tyr284) Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 488
Alternative name:	ALEXA FLUOR 488, Ack1 (Tyr284) (Antibody to)
Alternative technique:	antibodies

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