MSK1/2 Antibody, ALEXA FLUOR 594

Catalog number:	bs-2995R-A594 Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	MSK1/2 Antibody, ALEXA FLUOR 594
Quantity:	100ul
Related search:	msk alexa kinase antibody protein gene ser activated

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Long name:	ALEXA FLUOR 594 Conjugated, MSK1/2 Polyclonal Antibody
Also known as:	Anti-MSK1/2 PAb ALEXA FLUOR 594
Category:	Conjugated Primary Antibodies
Conjugated with:	594, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	MSK1/2
Specificity:	This is a highly specific antibody against MSK1/2
Modification:	Unmodified
Modification Site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	49-94/802
Subcellular location:	Nucleus
Source:	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MSK1
Gene ID Number:	8986, 9252
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	ATF1 H3 and HMG14 in response to mitogen and stress, Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), In lipopolysaccharide-stimulated primary macrophages, It is also known to be required for the phosphorylation of CREB, MSK1 autophosphorylate on at least 5 sites, MSK1 can be activated by ERK1/2 and SAPK2/p38 MAP kinase, MSK1 contains two kinase domains (N term and a C term), MSK2 plays an essential role in the control of RELA transcriptional activity in response to TNF, May also phosphorylate 'Ser-28' of histone H3, Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14), Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C terminal kinase domain of MSK1 which is essential for the catalytic activity of the N terminal kinase domain, Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, Similar to RSK, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines, including proto-oncogenes c-fos/FOS and c-jun/JUN, stress stimuli and EGF, via CREB1 and ATF1 transcription factors, which results in the transcriptional activation of several immediate early genes, MSK1 is a mitogen and stress activated protein kinase 1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	590nm/617nm
Synonyms:	MSK1 RLPK
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	594, ALEXA FLUOR®, Alexa Fluor
Conjugated:	Alexa conjugate 1
Gene target:	MSK1/2
Short name:	MSK1/2 Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 594
Alternative name:	ALEXA FLUOR 594, MSK1/2 (Antibody to)
Alternative technique:	antibodies
Identity:	10434
Gene:	RPS6KA5 | More about : RPS6KA5
Long gene name:	ribosomal protein S6 kinase A5
Synonyms gene name:	90kD, polypeptide 5 , ribosomal protein S6 kinase
Locus:	14q32, 11
Discovery year:	1999-03-10
GenBank acession:	AF074393
Entrez gene record:	9252
Pubmed identfication:	9687510 10702687
RefSeq identity:	NM_004755
Classification:	Mitogen-activated protein kinase-activated protein kinases
Havana BLAST/BLAT:	OTTHUMG00000171055

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