Polycystin 2 Antibody, Biotin Conjugated

Catalog number:	bs-2158R-Biotin Buy Now
Price:	263 €
Supplier:	Bioss Primary Unconjugated Antibodies
Product name:	Polycystin 2 Antibody, Biotin Conjugated
Quantity:	0.1ml
Related search:	antibody polycystin cilium biotin pkd protein signaling disease

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Long name:	Biotin Conjugated, Polycystin 2 Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Biotinylated
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	Polycystin 2
Specificity:	This antibody may have a minor secondary cross-reactivity towards Polycystin 2-like protein 1 due to a 71% non-contiguous sequence similarity in the immunogen sequence, This is a highly specific antibody against Polycystin 2
Modification:	Unmodified
Modification site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	680-720/968
Subcellular location:	Cytoplasm
Source:	KLH conjugated synthetic peptide derived from human Polycystin 2
Gene ID number:	5311
Swiss Prot:	Q13563
Tested applications:	IHC-P, WB
Recommended dilutions:	IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	Acts as a regulator of cilium length, Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning (By similarity), PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis, The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling, Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040), leads to cilium shortening and thus decreases flow-induced signaling, together with PKD1, which decreases intracellular cAMP, Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Synonyms:	APKD2, Autosomal dominant polycystic kidney disease type II protein, PKD2, PKD4, Pc-2, Polycystic kidney disease 2 protein, Polycystin-2, Polycystwin, R48321, TRPP2, Transient receptor potential cation channel subfamily P member 2, PC2
Properties:	Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target:	Polycystin 2 Conjugated
Short name:	Conjugated, Polycystin 2 Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Biotin
Alternative name:	biotinilated coupled, Polycystin 2 (Antibody to)
Alternative technique:	antibodies

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