Polycystin 2 Antibody

Catalog number:	bs-2158R Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	Polycystin 2 Antibody
Quantity:	0.1ml
Other quantities:	0.1mg 406€ 100ul 426€
Related search:	antibody polycystin cilium gene pkd protein disease involved

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Long name:	Polycystin 2 Primary Polyclonal Antibody
Also known as:	Polycystin 2 PAb
Category:	Primary Antibodies
Conjugation:	Unconjugated
Target Antigen:	Polycystin 2
Specificity:	This antibody may have a minor secondary cross-reactivity towards Polycystin 2-like protein 1 due to a 71% non-contiguous sequence similarity in the immunogen sequence, This is a highly specific antibody against Polycystin 2
Modification(s):	None
Modification site(s):	Unmodified antibody
Clonality:	Polyclonal antibody
Clone number:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	680-720/968
Subcellular location:	Cytoplasm
Source:	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Polycystin 2
Gene ID number:	5311
Swiss Prot:	Q13563
Tested Applications:	IF(IHC-P), IHC-P, WB
Recommended dilutions:	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity:	Mouse, Rat, Human
Cross reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen:	Acts as a regulator of cilium length, Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning (By similarity), PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis, The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling, Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040), leads to cilium shortening and thus decreases flow-induced signaling, together with PKD1, which decreases intracellular cAMP, Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names:	APKD2, Autosomal dominant polycystic kidney disease type II protein, PKD2, PKD4, Pc-2, Polycystic kidney disease 2 protein, Polycystin-2, Polycystwin, R48321, TRPP2, Transient receptor potential cation channel subfamily P member 2, PC2
Properties:	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target:	Polycystin 2
Short name:	Polycystin 2 Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Alternative name:	Polycystin 2 (Antibody to)
Alternative technique:	antibodies
Identity:	21715
Gene:	PKD1L2 | More about : PKD1L2
Long gene name:	polycystin 1 like 2 (gene/pseudogene)
Synonyms gene name:	polycystic kidney disease 1-like 2
Synonyms:	KIAA1879
Locus:	16q23, 2
Discovery year:	2003-08-05
GenBank acession:	AY164483
Entrez gene record:	114780
Pubmed identfication:	12782129
Classification:	C-type lectin domain containing
Havana BLAST/BLAT:	OTTHUMG00000166126

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