| Long name: |
ALEXA FLUOR 594 Conjugated, TRPV1/VR1 Polyclonal Antibody |
| Also known as: |
Anti-TRPV1/VR1 PAb ALEXA FLUOR 594 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
TRPV1/VR1 |
| Specificity: |
This is a highly specific antibody against TRPV1/VR1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
800-839/839 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human VR1 |
| Gene ID Number: |
7442 |
| Swiss Prot: |
Q8NER1 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Activation by vanilloids, Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects, Can be activated by endogenous compounds, Involved in mediation of inflammatory pain and hyperalgesia, Mild extracellular acidic pH (6, Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons, Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity), and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state, including 12-hydroperoxytetraenoic acid and bradykinin, like capsaicin, whereas acidic conditions (pH <, which involves PKC isozymes and PCL, 5) potentiates channel activation by noxious heat and vanilloids, 6) directly activate the channel, Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
590nm/617nm |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
594, ALEXA FLUOR®, Alexa Fluor |
| Conjugated: |
Alexa conjugate 1 |
| Gene target: |
TRPV1/VR1 |
| Short name: |
TRPV1/VR1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 594 |
| Alternative name: |
ALEXA FLUOR 594, TRPV1/VR1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12716 |
| Gene: |
TRPV1 |
More about : TRPV1 |
| Long gene name: |
transient receptor potential cation channel subfamily V member 1 |
| Synonyms gene: |
VR1 |
| Synonyms gene name: |
member 1 , subfamily V, vanilloid receptor subtype 1 transient receptor potential cation channel |
| Locus: |
17p13, 2 |
| Discovery year: |
1997-12-05 |
| GenBank acession: |
AJ272063 |
| Entrez gene record: |
7442 |
| Pubmed identfication: |
9349813 11549313 16382100 |
| RefSeq identity: |
NM_018727 |
| Classification: |
Ankyrin repeat domain containing Transient receptor potential cation channels |
| Havana BLAST/BLAT: |
OTTHUMG00000177649 |