| known also as: |
Anti-Rabbit Polyclonal (IgG) to Sheep SFN / Stratifin / 14-3-3 Sigma |
| known also as: |
Rabbit PAb (IgG) to Ovine SFN / Stratifin / 14-3-3 Sigma |
| known also as: |
Lapin Polyclonal (IgG) to Ovinae SFN / StRattus norvegicusifin / 14-3-3 Sigma |
| known also as: |
SFN / Stratifin / 14-3-3 Sigma |
| known also as: |
14-3-3 Sigma, 14-3-3 protein sigma, 14-3-3 sigma, HME1, SFN, Sheep SFN, Stratifin, Stratifin, YWHAS, Anti-SFN / Stratifin / 14-3-3 Sigma Antibody (N-Terminus) IHC-plus |
| Other names: |
14-3-3 protein sigma, 14-3-3 protein sigma, 14-3-3 sigma, Epithelial cell marker protein 1, Stratifin, epithelial cell marker protein 1, stratifin, 14-3-3 protein sigma |
| Gene name: |
SFN |
| Other gene names: |
HME1, SFN, YWHAS, SFN |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Chicken, Human, Mouse, Rabbit, Rat, Sheep <, /b>, Bovine, Mammal (at least 90% immunogen sequence identity), Predicted Reactivity: <, b> |
| Specificity and cross-reactivity: |
14-3-3 also negatively regulates both the glucocorticoid receptor and the activity of PKB/Akt which stabilizes p27 Kip1, 14-3-3 sigma binds c-fos activating the MAPK pathway, 14-3-3 sigma is expressed mostly in epithelial cells and has been associated with cancers including breast, 14-3-3 sigma targets, DeltaNp63alpha for proteasome degradation, In reaction to DNA damage and along with RACK1, It is a member of the 14-3-3 family which consists of 30 kD proteins that are involved in multiple protein kinase signalling pathways, May not react with recombinant proteins that are not N-acetylated, Mitosis is regulated by 14-3-3 sigma through binding keratin filaments and sequestering cyclin B1 and cdc2, Protein interactions with 14-3-3 show distinct preference for its different isotypes and are regulated by phosphorylation of both 14-3-3 and the bound protein, Sequestration of Bax by 14-3-3 sigma inhibits apoptosis whereas sequestration of 14-3-3 sigma by CARP-1 induces it, adenoid cystic, and papillary, colorectal, cytoskeletal structure, endometrial adenocarcinoma, epithelial ovarian, intracellular trafficking and targeting, nasopharyngeal, p73-dependent induction of 14-3-3 sigma regulates chemo sensitivity in breast cancers with p53 mutations, prostate, regulation of cell cycle progression, transcription, Recognizes 14-3-3 sigma in all mammals |
| Form/Appearance: |
0, 09% sodium azide, Serum |
| Storage and shipping: |
Avoid repeat freeze-thaw cycles, Short term: +Store productone at +4 degrees Celsius, Long term: Store productone at -20 degrees Celsius |
| Tested for:: |
Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| About: |
2 light chains, For storage sodium azide is added or you can call us to request azide free antibody preparations, IgG, The IgG antibody has 2 , There are 2 heavy chains, These will need colder storage temperatures, They represent 70% or more of , This antibody can be antigen purified or protein A or G purified, goat polyclonal antibodies , mouse monoclonal H&, Immunoglobulin gamma, L chain clones or rabbit, antibodies, antigen , binding sites, have 4 parts, serum |
| Gene target: |
PAb SFN / Stratifin / 14-3-3 Sigma |
| Short name: |
PAb (IgG) SFN / Stratifin / 14-3-3 Sigma Antibody |
| Technique: |
IgGs, antibodies against human proteins, antibodies for, Antibody |
| Host: |
Sheep |
| Isotype: |
IgG |
| Species: |
An adult female sheep is referred to as a , Sheep and goats are also used to produce polyclonals, Sheeps, Some epitopes will also recognize goat proteins, The , a , and a younger sheep as a , (Ovis aries) ELISAs are detecting sheep proteins and antigens, Sheep, a male as a , castrated , ewe , lamb, male as a , ram, sheep , wether |
| Alternative name: |
polyclonal (Immunoglobulin G) to ovine stratifin / Stratifin / 14-3-3 Sigma (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
SFN and IDBG-647781 and ENSBTAG00000009223 and 528453, SFN and IDBG-94738 and ENSG00000175793 and 2810, Sfn and IDBG-195282 and ENSMUSG00000047281 and 55948, YWHAS, nuclei, phosphoprotein binding, this GO :0000079 and regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0001836 and release of cytochrome c from mitochondria and biological process this GO :0003334 and keratinocyte development and biological process this GO :0005515 and protein binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0008426 and protein kinase C inhibitor activity and molecular function this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0010482 and regulation of epidermal cell division and biological process this GO :0010839 and negative regulation of keratinocyte proliferation and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0019904 and protein domain specific binding and molecular function this GO :0030216 and keratinocyte differentiation and biological process this GO :0030307 and positive regulation of cell growth and biological process this GO :0030659 and cytoplasmic vesicle membrane and cellular component this GO :0031424 and keratinization and biological process this GO :0043154 and negative regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0043588 and skin development and biological process this GO :0045606 and positive regulation of epidermal cell differentiation and biological process this GO :0046827 and positive regulation of protein export from nucleus and biological process this GO :0051219 and phosphoprotein binding and molecular function this GO :0051726 and regulation of cell cycle and biological process this GO :0061024 and membrane organization and biological process this GO :0061436 and establishment of skin barrier and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071901 and negative regulation of protein serine/threonine kinase activity and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :1900740 and positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008426 : protein kinase C inhibitor activity and also this GO :0019901 : protein kinase binding and also this GO :0019904 : protein domain specific binding and also this GO :0051219 : phosphoprotein binding, this GO :0008426 : protein kinase C inhibitor activity, this GO :0019901 : protein kinase binding, this GO :0019904 : protein domain specific binding, this GO :0051219 : phosphoprotein binding, stratifin |
| Identity: |
12854 |
| Gene: |
YWHAQ |
More about : YWHAQ |
| Long gene name: |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta |
| Synonyms gene name: |
theta , theta polypeptide protein, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein |
| Synonyms: |
HS1 14-3-3 |
| Synonyms name: |
protein tau |
| Locus: |
2p25, 1 |
| Discovery year: |
1999-08-20 |
| GenBank acession: |
AF070556 |
| Entrez gene record: |
10971 |
| Pubmed identfication: |
11080204 |
| RefSeq identity: |
NM_006826 |
| Classification: |
14-3-3 phospho-serine/phospho-threonine binding proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000013848 |