| Alternative name 1: |
Clone: 2A8, Mab anti-, SMAD6 |
| Alternative name 2: |
Clone: 2A8, Mab antibody-, SMAD6 |
| Alternative name 3: |
Clone: 2A8, Mab antibody-, SMAD6 |
| Alternative name 4: |
anti-SMAD6 Clone: 2A8 |
| Alternative name 5: |
SMAD6 Clone: 2A8 |
| Clonality: |
Monoclonal Antibody |
| Description: |
Amongst the advantages of the monoclonal antibodies are: the fact that while the hybridoma takes a bit longer to be produced, If used correctly and according the protocol, in comparison to the polyclonal antibodies monoclonal antibodies are highly specific to a given epitope and can be used in applications where specific targeting is required, once the line is ready there is virtually an endless supply of these antibodie throughout time with little to no variations in recognition sites of the antigen in different batches, this antibody will provide excellent and reproducible results with guaranteed success for the tested and confirmed applications, This is a monoclonal antibody which is greatly purified and with high binding affinity for the antigen that it is risen against |
| Storage and handling: |
Antibodies in a liquid form can be shipped and stored for a short period of time at +4 degrees Celsius, antibodies that are lyophilized can be transported at ambient temperature and stored for short terms at +4 degrees Celsius, for long term storage (up to one year) 25-50% glycerol or ethylene glycol should be added and then the container has to be stored at -20°, for longer periods - at -20 , C, Generally |
| Advisory: |
For antibodies in a liquid form or reconstituted lyophilized antibodies small amounts of the soultion could be captured on the cap or the walls of the container, Right before use you could briefly centrifuge the vial to collect all of the solution on the bottom, To keep the quality and the affinity of the antibody cycles of freezing and thawing should be avoided |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| French translation: |
anticorps |
| Gene target: |
Monoclonal 2A8, SMAD6 |
| Short name: |
Mouse Monoclonal antibody- Clone: 2A8, SMAD6 |
| Technique: |
Monoclonals or monoclonal antibodies, mouses, Mouse |
| Species: |
Mouses, Mouse |
| Alternative name: |
Mouse monoclonal (Antibody to)-, clonality: 2A8, SMAD family member 6 |
| Alternative technique: |
murine |
| Alternative to gene target: |
AOVD2 and HsT17432 and MADH6 and MADH7, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006955 and immune response and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007352 and zy this GO tic specification of dorsal/ventral axis and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0010991 and negative regulation of SMAD protein complex assembly and biological process this GO :0030509 and BMP signaling pathway and biological process this GO :0030512 and negative regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0030514 and negative regulation of BMP signaling pathway and biological process this GO :0030617 and transforming growth factor beta receptor, SMAD6 and IDBG-18304 and ENSG00000137834 and 4091, SMAD6 and IDBG-645465 and ENSBTAG00000000625 and 511279, Smad6 and IDBG-175757 and ENSMUSG00000036867 and 17130, inhibitory cytoplasmic mediator activity, inhibitory cytoplasmic mediator activity and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0034713 : type I transforming growth factor beta receptor binding and also this GO :0044212 : transcription regulatory region DNA binding and also this GO :0046872 : metal ion binding and also this GO :0070410 : co-SMAD binding and also this GO :0070411 : I-SMAD binding and also this GO :0070412 : R-SMAD binding and also this GO :0070698 : type I activin receptor binding, inhibitory cytoplasmic mediator activity and molecular function this GO :0031589 and cell-substrate adhesion and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0034616 and response to laminar fluid shear stress and biological process this GO :0034713 and type I transforming growth factor beta receptor binding and molecular function this GO :0035556 and intracellular signal transduction and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043234 and protein complex and cellular component this GO :0043627 and response to estrogen and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045444 and fat cell differentiation and biological process this GO :0046872 and metal ion binding and molecular function this GO :0060394 and negative regulation of pathway-restricted SMAD protein phosphorylation and biological process this GO :0070410 and co-SMAD binding and molecular function this GO :0070411 and I-SMAD binding and molecular function this GO :0070412 and R-SMAD binding and molecular function this GO :0070698 and type I activin receptor binding and molecular function, nuclei, this GO :0001657 and ureteric bud development and biological process this GO :0003682 and chromatin binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006351 and transcription, this GO :0003682 : chromatin binding, this GO :0003682 : chromatin binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0030617 : transforming growth factor beta receptor, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0030617 : transforming growth factor beta receptor, this GO :0031625 : ubiquitin protein ligase binding, this GO :0034713 : type I transforming growth factor beta receptor binding, this GO :0044212 : transcription regulatory region DNA binding, this GO :0046872 : metal ion binding, this GO :0070410 : co-SMAD binding, this GO :0070411 : I-SMAD binding, this GO :0070412 : R-SMAD binding, this GO :0070698 : type I activin receptor binding, transforming growth factor beta receptor, SMAD family member 6 |
| Identity: |
6772 |
| Gene: |
SMAD6 |
More about : SMAD6 |
| Long gene name: |
SMAD family member 6 |
| Synonyms gene: |
MADH7 MADH6 |
| Synonyms gene name: |
MAD, mothers against DPP homolog 6 (Drosophila) , mothers against decapentaplegic homolog 6 (Drosophila) SMAD |
| Synonyms: |
HsT17432 |
| Locus: |
15q22, 31 |
| Discovery year: |
1997-08-22 |
| GenBank acession: |
BC012986 |
| Entrez gene record: |
4091 |
| Pubmed identfication: |
9256479 |
| RefSeq identity: |
NM_005585 |
| Classification: |
SMAD family |
| Havana BLAST/BLAT: |
OTTHUMG00000133218 |
| Locus Specific Databases: |
The Globin Gene Server |