| Also known as: |
PRKDC / DNA-PKcs |
| Other names: |
DNA-PK catalytic subunit, DNA-activated, DNA-dependent protein kinase catalytic subunit, DNA-dependent protein kinase catalytic subunit, DNPK1, catalytic polypeptide, complementing 1, hyper-radiosensitivity of murine scid mutation, p460, p460, protein kinase, DNA-dependent protein kinase catalytic subunit isoform 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
PRKDC |
| Other gene names: |
DNA-PK catalytic subunit, DNA-PKcs, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC, HYRC1, HYRC1, IMD26, PRKDC, XRCC7, p350, PRKDC |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a, k |
| Clone: |
2A8 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, Human DNA PKcs |
| Purification method: |
Protein A Purified |
| Form/Appearance: |
pH 7, 2, PBS |
| Concentration: |
25 mg/ml |
| Storage and shipping: |
For long term storage aliquot and keep the antibody at -20 degrees Celsius, Freeze-thaw cycles should be avoided in order to retain the activity of the antibody, Store at +4 degrees Celsius for short term storage |
| Tested applications:: |
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ 2A8] (IgG2a, k) PRKDC / DNA-PKcs |
| Short name: |
Mouse Monoclonal [clone 2A8] (IgG2a, k) PRKDC / DNA-PKcs Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG2a |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
Desoxyribonucleic acid-activated, catalytic polypeptide / Desoxyribonucleic acid-PKcs (Antibody to), sapiens protein kinase, Mouse monoclonal [clonality 2A8] (IgG2a, k) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-PKcs and DNAPK and DNPK1 and HYRC and HYRC1 and IMD26 and p350 and XRCC7, DNA-activated, PRKDC and IDBG-408612 and ENSG00000253729 and 5591, PRKDC and IDBG-644289 and ENSBTAG00000017019 and 512740, Prkdc and IDBG-135771 and ENSMUSG00000022672 and 19090, alcohol group as acceptor, alcohol group as acceptor and also this GO :0019899 : enzyme binding and also this GO :0044822 : poly(A) RNA binding, alcohol group as acceptor and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0019899 and enzyme binding and molecular function this GO :0030098 and lymphocyte differentiation and biological process this GO :0031648 and protein destabilization and biological process this GO :0032481 and positive regulation of type I interferon production and biological process this GO :0032869 and cellular response to insulin stimulus and biological process this GO :0033077 and T cell differentiation in thymus and biological process this GO :0033152 and immunoglobulin V(D)J recombination and biological process this GO :0033153 and T cell receptor V(D)J recombination and biological process this GO :0035234 and ectopic germ cell programmed cell death and biological process this GO :0042752 and regulation of circadian rhythm and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0044822 and poly(A) RNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048511 and rhythmic process and biological process this GO :0070419 and nonhomolo this GO us end joining complex and cellular component this GO :0072431 and signal transduction involved in mitotic G1 DNA damage checkpoint and biological process, catalytic polypeptide, nuclei, this GO :0000723 and telomere maintenance and biological process this GO :0001756 and somitogenesis and biological process this GO :0001933 and negative regulation of protein phosphorylation and biological process this GO :0002326 and B cell lineage commitment and biological process this GO :0002328 and pro-B cell differentiation and biological process this GO :0002360 and T cell lineage commitment and biological process this GO :0003677 and DNA binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004677 and DNA-dependent protein kinase activity and molecular function this GO :0005488 and binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005958 and DNA-dependent protein kinase-DNA ligase 4 complex and cellular component this GO :0006281 and DNA repair and biological process this GO :0006302 and double-strand break repair and biological process this GO :0006303 and double-strand break repair via nonhomolo this GO us end joining and biological process this GO :0006464 and cellular protein modification process and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0007420 and brain development and biological process this GO :0007507 and heart development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0010332 and response to gamma radiation and biological process this GO :0016020 and membrane and cellular component this GO :0016772 and transferase activity, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004677 : DNA-dependent protein kinase activity and also this GO :0005488 : binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008134 : transcription factor binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004677 : DNA-dependent protein kinase activity, this GO :0005488 : binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008134 : transcription factor binding, this GO :0016772 : transferase activity, this GO :0016773 : phosphotransferase activity, this GO :0019899 : enzyme binding, this GO :0044822 : poly(A) RNA binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0016773 : phosphotransferase activity, transferring phosphorus-containing groups and molecular function this GO :0016773 and phosphotransferase activity, protein kinase |
| Identity: |
9413 |
| Gene: |
PRKDC |
More about : PRKDC |
| Long gene name: |
DNA-activated, catalytic polypeptide , protein kinase |
| Synonyms gene: |
HYRC HYRC1 |
| Synonyms: |
DNPK1 p350 DNAPK XRCC7 DNA-PKcs |
| Locus: |
8q11, 21 |
| Discovery year: |
1993-11-09 |
| Entrez gene record: |
5591 |
| Pubmed identfication: |
7638222 |
| RefSeq identity: |
NM_001081640 |
| Havana BLAST/BLAT: |
OTTHUMG00000164239 |
| Locus Specific Databases: |
LRG_162 |