| Long name: |
NSP3 Primary Polyclonal Antibody |
| Also known as: |
NSP3 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
NSP3 |
| Specificity: |
This is a highly specific antibody against NSP3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NSP3 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
FAN (for factor associated with neutral sphingomyelinase (N-SMase) activation) is an intermediate protein that interacts with TNF-R1 to initiate TNF signaling events, FAN binds to TNF-R1 at the cytoplasmic NSD (N-SMase activating domain), FAN contains four carboxy-terminal WD-repeat domains which appear to be involved in protein-protein interaction, N-SMase has been shown to be involved in TNF-induced Raf-1 activation (6), The FAN WD-repeats may mediate the interaction between FAN and TNF-R1 (5), The majority of TNF functions are primarily mediated through TNF-R1 (1, These receptors, are expressed on most cell types (1, designated TNF-R1 and TNF-R2, which results in the initiation of the N-SMase pathway (5), 2), 3), 4), Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors (1 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CHAT, FLJ39664, NSP 3, Novel SH2 containing protein 3, Novel SH2-containing protein 3, PRO34088, SH2 domain containing 3C, SH2 domain containing Eph receptor binding protein 1, SH2 domain containing protein 3C, SH2 domain-containing protein 3C, SH2D3C, SH2D3_HUMAN, Shep1, Cas/HEF1 associated signal transducer |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
NSP3 |
| Short name: |
NSP3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
NSP3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
16884 |
| Gene: |
SH2D3C |
More about : SH2D3C |
| Long gene name: |
SH2 domain containing 3C |
| Synonyms gene name: |
SH2 domain-containing 3C |
| Synonyms: |
NSP3 |
| Locus: |
9q34, 11 |
| Discovery year: |
2001-11-19 |
| GenBank acession: |
AF124251 |
| Entrez gene record: |
10044 |
| Pubmed identfication: |
10187783 |
| RefSeq identity: |
NM_005489 |
| Classification: |
SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000020717 |