| Long name: |
HRP Conjugated, IKAP Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
HRP Conjugated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
IKAP |
| Specificity: |
This is a highly specific antibody against IKAP |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human IKAP |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Activation of NFkB requires that IkB be phosphorylated on specific serine residues, IKAP (IKK-complex-associated protein) is a protein that acts as a scaffold, IKK alpha, IKK alpha and IKK beta and assembling them into an active kinase complex (7, IKK beta and IKK gamma (also designated NEMO), IKKalpha appears to be critical for NFkB activation in response to proinflammatory cytokines (4), IkB kinase alpha (IKK alpha), Phosphorylation of the IkB by IKK alpha is stimulated by the NFkB inducing kinase (NIK), The functional IKK complex contains three subunits, and each appears to make essential contributions to IkB phosphorylation (6), interacting with NIK, interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation, previously designated CHUK (2), serines 32 and 36 (3), which itself is a central regulator for NFkB activation in response to TNF and IL-1 (5), which results in the targeted degradation of IkB (1), 8), The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% Gentamicin, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
IKAP TOT1 ELP1 IKI3 |
| Properties: |
Also monoclonal HRP conjugates are often used for Western Blot, HRP conjugates are often primary rabbit polyclonal antibodies couples to the , found in the roots of , (HRP), C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°, enzyme , horseradish, horseradish peroxidase |
| Gene target: |
IKAP Conjugated |
| Short name: |
Conjugated, IKAP Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
HRP |
| Alternative name: |
horseradish peroxidase coupled, IKAP (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
5959 |
| Gene: |
IKBKAP |
More about : IKBKAP |
| Long gene name: |
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein |
| Synonyms gene: |
DYS |
| Synonyms gene name: |
dysautonomia (Riley-Day syndrome, hereditary sensory autonomic neuropathy type III) |
| Synonyms name: |
elongator acetyltransferase complex subunit 1 |
| Locus: |
9q31, 3 |
| Discovery year: |
1998-09-30 |
| GenBank acession: |
AF044195 |
| Entrez gene record: |
8518 |
| Pubmed identfication: |
9751059 11179008 |
| Classification: |
Elongator acetyltransferase complex |
| Havana BLAST/BLAT: |
OTTHUMG00000020465 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_251 |