| Long name: |
IKAP Primary Polyclonal Antibody |
| Also known as: |
IKAP PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
IKAP |
| Specificity: |
This is a highly specific antibody against IKAP |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human IKAP |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activation of NFkB requires that IkB be phosphorylated on specific serine residues, IKAP (IKK-complex-associated protein) is a protein that acts as a scaffold, IKK alpha, IKK alpha and IKK beta and assembling them into an active kinase complex (7, IKK beta and IKK gamma (also designated NEMO), IKKalpha appears to be critical for NFkB activation in response to proinflammatory cytokines (4), IkB kinase alpha (IKK alpha), Phosphorylation of the IkB by IKK alpha is stimulated by the NFkB inducing kinase (NIK), The functional IKK complex contains three subunits, and each appears to make essential contributions to IkB phosphorylation (6), interacting with NIK, interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation, previously designated CHUK (2), serines 32 and 36 (3), which itself is a central regulator for NFkB activation in response to TNF and IL-1 (5), which results in the targeted degradation of IkB (1), 8), The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
DYS, Dysautonomia Riley Day syndrome hereditary sensory autonomic neuropathy type III, ELP 1, ELP1, ELP1_HUMAN, Elongator complex protein 1, FD, FLJ12497, IKAP, IKI 3, IKI3, IKK complex associated protein, IKK complex-associated protein, IkappaB kinase complex associated protein, IkappaB kinase complex-associated protein, Inhibitor of kappa light polypeptide gene enhancer in B cells kinase complex associated protein, OTTHUMP00000063889, TOT 1, TOT1, ikbkap, p150, DKFZp781H1425 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
IKAP |
| Short name: |
IKAP Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
IKAP (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
5959 |
| Gene: |
IKBKAP |
More about : IKBKAP |
| Long gene name: |
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein |
| Synonyms gene: |
DYS |
| Synonyms gene name: |
dysautonomia (Riley-Day syndrome, hereditary sensory autonomic neuropathy type III) |
| Synonyms: |
IKAP TOT1 ELP1 IKI3 |
| Synonyms name: |
elongator acetyltransferase complex subunit 1 |
| Locus: |
9q31, 3 |
| Discovery year: |
1998-09-30 |
| GenBank acession: |
AF044195 |
| Entrez gene record: |
8518 |
| Pubmed identfication: |
9751059 11179008 |
| Classification: |
Elongator acetyltransferase complex |
| Havana BLAST/BLAT: |
OTTHUMG00000020465 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_251 |