| Long name: |
ALEXA FLUOR 488 Conjugated, GAB4 Polyclonal Antibody |
| Also known as: |
Anti-GAB4 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
GAB4 |
| Specificity: |
This is a highly specific antibody against GAB4 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GAB4 |
| Gene ID Number: |
128954 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, Gab 1-4 contain Pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins, Gab 4 (GRB2-associated-binding protein 4), Insulin receptor and EGF receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus, The recruitment of signaling partners to Gab family members is phosphorylation-dependent, This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes, also designated GRB2-associated-binding protein 2-like (Gab 2-like), is a 574 amino acid protein that shares 62% sequence similarity with Gab 2 and contains one Pleckstrin homology domain, proliferation and differentiation occur, The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recruit-ment to RTKs |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the GAB4 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
GAB4 |
| Short name: |
GAB4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, member 4 (Antibody to), GRB2-associated binding protein family |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
GAB2 and IDBG-642116 and ENSBTAG00000002922 and 529346, GAB4 and IDBG-227875 and ENSG00000215568 and 128954, Gab2 and IDBG-199566 and ENSMUSG00000004508 and 14389, member 4, multiple, GRB2-associated binding protein family |
| Identity: |
18325 |
| Gene: |
GAB4 |
More about : GAB4 |
| Long gene name: |
GRB2 associated binding protein family member 4 |
| Synonyms gene name: |
GRB2-associated binding protein family, member 4 |
| Locus: |
22q11, 1 |
| Discovery year: |
2004-07-22 |
| GenBank acession: |
AK057252 |
| Entrez gene record: |
128954 |
| RefSeq identity: |
XM_372882 |
| Classification: |
Pleckstrin homology domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000149992 |