| Long name: |
Frizzled 10/CD350 Primary Polyclonal Antibody |
| Also known as: |
Frizzled 10/CD350 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Frizzled 10/CD350 |
| Specificity: |
Due to the similarity of this protein to Frizzled 9, there is a chance that this antibody will react with this protein based on homology, This is a highly specific antibody against Frizzled 10/CD350 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
100-150/581 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Frizzled 10/CD350 |
| Gene ID number: |
11211 |
| Swiss Prot: |
Q9ULW2 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, Both pathways seem to involve interactions with G-proteins, May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues, Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes, which leads to the activation of disheveled proteins, Receptor for Wnt proteins |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CD350, FZ-10, FZD10, Frizzled-10, FzE7, hFz10, Fz10 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Frizzled 10/CD350 |
| Short name: |
Frizzled 10/CD350 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Frizzled 10/CD350 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4039 |
| Gene: |
FZD10 |
More about : FZD10 |
| Long gene name: |
frizzled class receptor 10 |
| Synonyms gene name: |
frizzled (Drosophila) homolog 10 frizzled homolog 10 (Drosophila) frizzled 10, seven transmembrane spanning receptor frizzled family receptor 10 |
| Synonyms: |
CD350 |
| Locus: |
12q24, 33 |
| Discovery year: |
1999-09-09 |
| GenBank acession: |
AB027464 |
| Entrez gene record: |
11211 |
| Pubmed identfication: |
10448064 |
| Classification: |
Class F frizzled CD molecules , G protein-coupled receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000168380 |