| Long name: |
Biotin Conjugated, GREM2 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
GREM2 |
| Specificity: |
This is a highly specific antibody against GREM2 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human GREM2 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Additionally, All family members are secreted proteins that act as BMP antagonists in embryonic explants and are expressed in the proximal airway epithelium of the lung during embryonic development, Gremlin-1 is required for early limb outgrowth and patterning in the FGF4-SHH feedback loop, The dorsaling factor gremlin belongs to a novel gene family that includes the head-inducing factor Cerberus and the tumor suppressor DAN, secreted gremlin relays the sonic hedgehog signal from the polarizing region to the apical ectodermal ridge, while gremlin-2 binds and blocks the activity of BMP-2 and BMP-4, The gremlin protein family contains antagonists of bone morphogenetic protein (BMP) signaling that are expressed in the neural crest |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
Prdc FLJ21195 CKTSF1B2 DAND3 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
GREM2 Conjugated |
| Short name: |
Conjugated, GREM2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, gremlin 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Extracellular, GREM2 and IDBG-107671 and ENSG00000180875 and 64388, Grem2 and IDBG-206362 and ENSMUSG00000050069 and 23893, protein homodimerization activity, this GO :0005125 and cytokine activity and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0008201 and heparin binding and molecular function this GO :0010172 and embryonic body morphogenesis and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0030509 and BMP signaling pathway and biological process this GO :0030514 and negative regulation of BMP signaling pathway and biological process this GO :0036122 and BMP binding and molecular function this GO :0038098 and sequestering of BMP from receptor via BMP binding and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0048263 and determination of dorsal identity and biological process this GO :0060300 and regulation of cytokine activity and biological process, this GO :0005125 : cytokine activity, this GO :0005125 : cytokine activity and also this GO :0008201 : heparin binding and also this GO :0036122 : BMP binding and also this GO :0042803 : protein homodimerization activity, this GO :0008201 : heparin binding, this GO :0036122 : BMP binding, this GO :0042803 : protein homodimerization activity, gremlin 2 |
| Identity: |
17655 |
| Gene: |
GREM2 |
More about : GREM2 |
| Long gene name: |
DAN family BMP antagonist , gremlin 2 |
| Synonyms gene name: |
cysteine knot superfamily, gremlin 2, homolog (Xenopus laevis) gremlin 2 |
| Synonyms name: |
protein related to DAN and cerberus |
| Locus: |
1q43 |
| Discovery year: |
2004-07-30 |
| GenBank acession: |
AK024848 |
| Entrez gene record: |
64388 |
| Pubmed identfication: |
15039429 |
| RefSeq identity: |
NM_022469 |
| Classification: |
DAN family |
| Havana BLAST/BLAT: |
OTTHUMG00000039909 |