| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
GREM2 |
| Specificity: |
This antibody reacts specifically with GREM2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human GREM2 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Additionally, All family members are secreted proteins that act as BMP antagonists in embryonic explants and are expressed in the proximal airway epithelium of the lung during embryonic development, Gremlin-1 is required for early limb outgrowth and patterning in the FGF4-SHH feedback loop, The dorsaling factor gremlin belongs to a novel gene family that includes the head-inducing factor Cerberus and the tumor suppressor DAN, secreted gremlin relays the sonic hedgehog signal from the polarizing region to the apical ectodermal ridge, while gremlin-2 binds and blocks the activity of BMP-2 and BMP-4, The gremlin protein family contains antagonists of bone morphogenetic protein (BMP) signaling that are expressed in the neural crest |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Prdc FLJ21195 CKTSF1B2 DAND3 |
| Also known as: |
GREM2 Polyclonal Antibody |
| Other name: |
Anti-GREM2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
GREM2 |
| Short name: |
Anti-GREM2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-gremlin 2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
Extracellular, GREM2 and IDBG-107671 and ENSG00000180875 and 64388, Grem2 and IDBG-206362 and ENSMUSG00000050069 and 23893, protein homodimerization activity, this GO :0005125 and cytokine activity and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0008201 and heparin binding and molecular function this GO :0010172 and embryonic body morphogenesis and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0030509 and BMP signaling pathway and biological process this GO :0030514 and negative regulation of BMP signaling pathway and biological process this GO :0036122 and BMP binding and molecular function this GO :0038098 and sequestering of BMP from receptor via BMP binding and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0048263 and determination of dorsal identity and biological process this GO :0060300 and regulation of cytokine activity and biological process, this GO :0005125 : cytokine activity, this GO :0005125 : cytokine activity and also this GO :0008201 : heparin binding and also this GO :0036122 : BMP binding and also this GO :0042803 : protein homodimerization activity, this GO :0008201 : heparin binding, this GO :0036122 : BMP binding, this GO :0042803 : protein homodimerization activity, gremlin 2 |
| Identity: |
17655 |
| Gene: |
GREM2 |
More about : GREM2 |
| Long gene name: |
DAN family BMP antagonist , gremlin 2 |
| Synonyms gene name: |
cysteine knot superfamily, gremlin 2, homolog (Xenopus laevis) gremlin 2 |
| Synonyms name: |
protein related to DAN and cerberus |
| Locus: |
1q43 |
| Discovery year: |
2004-07-30 |
| GenBank acession: |
AK024848 |
| Entrez gene record: |
64388 |
| Pubmed identfication: |
15039429 |
| RefSeq identity: |
NM_022469 |
| Classification: |
DAN family |
| Havana BLAST/BLAT: |
OTTHUMG00000039909 |