| Long name: |
ADAM17 (Thr735) Primary Polyclonal Antibody |
| Also known as: |
ADAM17 (Thr735) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
ADAM17 Thr735 |
| Specificity: |
This is a highly specific antibody against ADAM17 Thr735 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Thr735 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human ADAM17 around the phosphorylation site of Thr735 |
| Gene ID number: |
6868 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme, [provided by RefSeq], and also plays a prominent role in the activation of the Notch signaling pathway, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, and neurogenesis, binds mitotic arrest deficient 2 protein, including fertilization, muscle development, This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
A disintegrin and metalloproteinase domain 17 tumor necrosis factor, ADAM 17, ADAM metallopeptidase domain 17, ADAM17 protein, CD 156b, CD156b, CD156b antigen, CSVP, MGC71942, Snake venom like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme, Tumor Necrosis Factor Alpha Converting Enzyme, alpha, converting enzyme, p-ADAM17 phospho T735, p-CD156bphospho T735, A disintegrin and metalloproteinase domain 17, ADAM17 phospho T735 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
ADAM17 (Thr735) |
| Short name: |
ADAM17 (Thr735) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ADAM metallopeptidase domain 17 (Thr735) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ADAM17 and IDBG-27788 and ENSG00000151694 and 6868, ADAM17 and IDBG-638333 and ENSBTAG00000001141 and 517541, ADAM18 and CD156B and CSVP and NISBD and TACE, Adam17 and IDBG-130508 and ENSMUSG00000052593 and 11491, Cell surfaces, PDZ domain binding, spreading of epidermal cells and biological process this GO :0035625 and epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway and biological process this GO :0042493 and response to drug and biological process this GO :0045121 and membrane raft and cellular component this GO :0045741 and positive regulation of epidermal growth factor-activated receptor activity and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048536 and spleen development and biological process this GO :0048870 and cell motility and biological process this GO :0051088 and PMA-inducible membrane protein ectodomain proteolysis and biological process this GO :0051272 and positive regulation of cellular component movement and biological process this GO :0055099 and response to high density lipoprotein particle stimulus and biological process this GO :0060397 and JAK-STAT cascade involved in growth hormone signaling pathway and biological process this GO :0097190 and apoptotic signaling pathway and biological process, this GO :0001666 and response to hypoxia and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0002446 and neutrophil mediated immunity and biological process this GO :0002467 and germinal center formation and biological process this GO :0002690 and positive regulation of leukocyte chemotaxis and biological process this GO :0004222 and metalloendopeptidase activity and molecular function this GO :0005112 and Notch binding and molecular function this GO :0005138 and interleukin-6 receptor binding and molecular function this GO :0005178 and integrin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0005925 and focal adhesion and cellular component this GO :0006508 and proteolysis and biological process this GO :0006509 and membrane protein ectodomain proteolysis and biological process this GO :0006915 and apoptotic process and biological process this GO :0007155 and cell adhesion and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007220 and Notch receptor processing and biological process this GO :0008237 and metallopeptidase activity and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009986 and cell surface and cellular component this GO :0010820 and positive regulation of T cell chemotaxis and biological process this GO :0015629 and actin cytoskeleton and cellular component this GO :0016020 and membrane and cellular component this GO :0016324 and apical plasma membrane and cellular component this GO :0017124 and SH3 domain binding and molecular function this GO :0022617 and extracellular matrix disassembly and biological process this GO :0030165 and PDZ domain binding and molecular function this GO :0030183 and B cell differentiation and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030307 and positive regulation of cell growth and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0030511 and positive regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0030512 and negative regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0030574 and collagen catabolic process and biological process this GO :0031293 and membrane protein intracellular domain proteolysis and biological process this GO :0031659 and positive regulation of cyclin-dependent protein kinase activity involved in G1/S and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032587 and ruffle membrane and cellular component this GO :0032717 and negative regulation of interleukin-8 production and biological process this GO :0032722 and positive regulation of chemokine production and biological process this GO :0033025 and regulation of mast cell apoptotic process and biological process this GO :0033077 and T cell differentiation in thymus and biological process this GO :0033627 and cell adhesion mediated by integrin and biological process this GO :0035313 and wound healing, this GO :0004222 : metalloendopeptidase activity, this GO :0004222 : metalloendopeptidase activity and also this GO :0005112 : Notch binding and also this GO :0005138 : interleukin-6 receptor binding and also this GO :0005178 : integrin binding and also this GO :0005515 : protein binding and also this GO :0008237 : metallopeptidase activity and also this GO :0008270 : zinc ion binding and also this GO :0017124 : SH3 domain binding and also this GO :0030165 : PDZ domain binding, this GO :0005112 : Notch binding, this GO :0005138 : interleukin-6 receptor binding, this GO :0005178 : integrin binding, this GO :0005515 : protein binding, this GO :0008237 : metallopeptidase activity, this GO :0008270 : zinc ion binding, this GO :0017124 : SH3 domain binding, this GO :0030165 : PDZ domain binding, ADAM metallopeptidase domain 17 |
| Identity: |
195 |
| Gene: |
ADAM17 |
More about : ADAM17 |
| Long gene name: |
ADAM metallopeptidase domain 17 |
| Synonyms gene: |
TACE |
| Synonyms gene name: |
alpha, converting enzyme , tumor necrosis factor |
| Synonyms: |
cSVP CD156B |
| Locus: |
2p25, 1 |
| Discovery year: |
1997-04-10 |
| GenBank acession: |
U69611 |
| Entrez gene record: |
6868 |
| Pubmed identfication: |
9034190 9574564 |
| Classification: |
ADAM metallopeptidase domain containing CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000090425 |