| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ADAM17 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the ADAM17 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This ADAM17 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P78536 |
| Purity: |
Antigen affinity |
| Description: |
ADAM17 functions as a tumor necrosis factor-alpha converting enzyme, Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and also plays a prominent role in the activation of the Notch signaling pathway, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, and neurogenesis, binds mitotic arrest deficient 2 protein, including fertilization, muscle development, ADAM17 is a member of the ADAM (a disintegrin and metalloprotease domain) family |
| Immunogen: |
A portion of amino acids 195-224 from the human protein was used as the immunogen for this ADAM17 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the ADAM17 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ADAM17 |
| Short name: |
ADAM17 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ADAM metallopeptidase domain 17 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ADAM17 and IDBG-27788 and ENSG00000151694 and 6868, ADAM17 and IDBG-638333 and ENSBTAG00000001141 and 517541, ADAM18 and CD156B and CSVP and NISBD and TACE, Adam17 and IDBG-130508 and ENSMUSG00000052593 and 11491, Cell surfaces, PDZ domain binding, spreading of epidermal cells and biological process this GO :0035625 and epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway and biological process this GO :0042493 and response to drug and biological process this GO :0045121 and membrane raft and cellular component this GO :0045741 and positive regulation of epidermal growth factor-activated receptor activity and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048536 and spleen development and biological process this GO :0048870 and cell motility and biological process this GO :0051088 and PMA-inducible membrane protein ectodomain proteolysis and biological process this GO :0051272 and positive regulation of cellular component movement and biological process this GO :0055099 and response to high density lipoprotein particle stimulus and biological process this GO :0060397 and JAK-STAT cascade involved in growth hormone signaling pathway and biological process this GO :0097190 and apoptotic signaling pathway and biological process, this GO :0001666 and response to hypoxia and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0002446 and neutrophil mediated immunity and biological process this GO :0002467 and germinal center formation and biological process this GO :0002690 and positive regulation of leukocyte chemotaxis and biological process this GO :0004222 and metalloendopeptidase activity and molecular function this GO :0005112 and Notch binding and molecular function this GO :0005138 and interleukin-6 receptor binding and molecular function this GO :0005178 and integrin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0005925 and focal adhesion and cellular component this GO :0006508 and proteolysis and biological process this GO :0006509 and membrane protein ectodomain proteolysis and biological process this GO :0006915 and apoptotic process and biological process this GO :0007155 and cell adhesion and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007220 and Notch receptor processing and biological process this GO :0008237 and metallopeptidase activity and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009986 and cell surface and cellular component this GO :0010820 and positive regulation of T cell chemotaxis and biological process this GO :0015629 and actin cytoskeleton and cellular component this GO :0016020 and membrane and cellular component this GO :0016324 and apical plasma membrane and cellular component this GO :0017124 and SH3 domain binding and molecular function this GO :0022617 and extracellular matrix disassembly and biological process this GO :0030165 and PDZ domain binding and molecular function this GO :0030183 and B cell differentiation and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030307 and positive regulation of cell growth and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0030511 and positive regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0030512 and negative regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0030574 and collagen catabolic process and biological process this GO :0031293 and membrane protein intracellular domain proteolysis and biological process this GO :0031659 and positive regulation of cyclin-dependent protein kinase activity involved in G1/S and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032587 and ruffle membrane and cellular component this GO :0032717 and negative regulation of interleukin-8 production and biological process this GO :0032722 and positive regulation of chemokine production and biological process this GO :0033025 and regulation of mast cell apoptotic process and biological process this GO :0033077 and T cell differentiation in thymus and biological process this GO :0033627 and cell adhesion mediated by integrin and biological process this GO :0035313 and wound healing, this GO :0004222 : metalloendopeptidase activity, this GO :0004222 : metalloendopeptidase activity and also this GO :0005112 : Notch binding and also this GO :0005138 : interleukin-6 receptor binding and also this GO :0005178 : integrin binding and also this GO :0005515 : protein binding and also this GO :0008237 : metallopeptidase activity and also this GO :0008270 : zinc ion binding and also this GO :0017124 : SH3 domain binding and also this GO :0030165 : PDZ domain binding, this GO :0005112 : Notch binding, this GO :0005138 : interleukin-6 receptor binding, this GO :0005178 : integrin binding, this GO :0005515 : protein binding, this GO :0008237 : metallopeptidase activity, this GO :0008270 : zinc ion binding, this GO :0017124 : SH3 domain binding, this GO :0030165 : PDZ domain binding, ADAM metallopeptidase domain 17 |
| Identity: |
195 |
| Gene: |
ADAM17 |
More about : ADAM17 |
| Long gene name: |
ADAM metallopeptidase domain 17 |
| Synonyms gene: |
TACE |
| Synonyms gene name: |
alpha, converting enzyme , tumor necrosis factor |
| Synonyms: |
cSVP CD156B |
| Locus: |
2p25, 1 |
| Discovery year: |
1997-04-10 |
| GenBank acession: |
U69611 |
| Entrez gene record: |
6868 |
| Pubmed identfication: |
9034190 9574564 |
| Classification: |
ADAM metallopeptidase domain containing CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000090425 |