| Long name: |
PE Conjugated, SLC5A3/SMIT Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
PE |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SLC5A3/SMIT |
| Specificity: |
This is a highly specific antibody against SLC5A3/SMIT |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
KLH conjugated synthetic peptide derived from human SLC5A3/SMIT |
| Tested applications: |
FCM |
| Recommended dilutions: |
FCM(1:20-100) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Impaired SMIT activity is implicated in the pathogenesis of diabetes and Down syndrome, In kidney, It is expressed in many human tissues, It is taken up into cells by the sodium/myo-inositol cotransporter (SMIT), SMIT activity maintains intracellular concentrations of myo-inositol, SMIT is abundantly expressed throughout the whole brain and spinal cord in fetal rat, SMIT localizes to the baso-lateral membranes of the thick ascending limb of Henle (TAL) and the inner medullary collecting duct (IMCD), Specifically, The human SMIT protein is encoded by the SLC5A3 gene, but is downregulated in adult rat brain with the exception of the choroid plexus, it is upregulated in response to hypertonic stress, kidney and placenta, signal transduction and osmoregulation, such as brain, where SMIT expression remains high, which maps to chromosome 21q22, 12, Myo-inositol is involved in many important aspects of cellular regulation including membrane structure |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
480, 565nm/578nm |
| Synonyms: |
SMIT SMIT1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
SLC5A3/SMIT PE Conjugated |
| Short name: |
PE Conjugated, SLC5A3/SMIT Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
PE |
| Alternative name: |
peroxidase coupled, SLC5A3/SMIT (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11038 |
| Gene: |
SLC5A3 |
More about : SLC5A3 |
| Long gene name: |
solute carrier family 5 member 3 |
| Synonyms gene name: |
member 3 , member 3 solute carrier family 5 (sodium/myo-inositol cotransporter), solute carrier family 5 (inositol transporter) |
| Locus: |
21q22, 11 |
| Discovery year: |
1994-02-15 |
| Entrez gene record: |
6526 |
| Pubmed identfication: |
7789985 |
| Classification: |
Solute carriers |
| Havana BLAST/BLAT: |
OTTHUMG00000065821 |