| Long name: |
ALEXA FLUOR 555 Conjugated, SLC5A3/SMIT Polyclonal Antibody |
| Also known as: |
Anti-SLC5A3/SMIT PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SLC5A3/SMIT |
| Specificity: |
This is a highly specific antibody against SLC5A3/SMIT |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SLC5A3/SMIT |
| Tested applications: |
IF(IHC-P), FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Impaired SMIT activity is implicated in the pathogenesis of diabetes and Down syndrome, In kidney, It is expressed in many human tissues, It is taken up into cells by the sodium/myo-inositol cotransporter (SMIT), SMIT activity maintains intracellular concentrations of myo-inositol, SMIT is abundantly expressed throughout the whole brain and spinal cord in fetal rat, SMIT localizes to the baso-lateral membranes of the thick ascending limb of Henle (TAL) and the inner medullary collecting duct (IMCD), Specifically, The human SMIT protein is encoded by the SLC5A3 gene, but is downregulated in adult rat brain with the exception of the choroid plexus, it is upregulated in response to hypertonic stress, kidney and placenta, signal transduction and osmoregulation, such as brain, where SMIT expression remains high, which maps to chromosome 21q22, 12, Myo-inositol is involved in many important aspects of cellular regulation including membrane structure |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
SMIT SMIT1 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
SLC5A3/SMIT |
| Short name: |
SLC5A3/SMIT Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, SLC5A3/SMIT (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11038 |
| Gene: |
SLC5A3 |
More about : SLC5A3 |
| Long gene name: |
solute carrier family 5 member 3 |
| Synonyms gene name: |
member 3 , member 3 solute carrier family 5 (sodium/myo-inositol cotransporter), solute carrier family 5 (inositol transporter) |
| Locus: |
21q22, 11 |
| Discovery year: |
1994-02-15 |
| Entrez gene record: |
6526 |
| Pubmed identfication: |
7789985 |
| Classification: |
Solute carriers |
| Havana BLAST/BLAT: |
OTTHUMG00000065821 |