| Long name: |
FITC Conjugated, PTF1A Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PTF1A |
| Specificity: |
This is a highly specific antibody against PTF1A |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
KLH conjugated synthetic peptide derived from human PTF1A |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Localizing to the nucleus, Loss of functional PTF1 can cause pancreatic progenitors to take on the normal fates of duodenal epithelia, Mutations in the gene encoding PTF1 lead to diabetes mellitus and cerebellar hypoplasia/agenesis, PTF1 contains one basic helix-loop-helix (bHLH) domain and is believed to play an important role in mammalian pancreatic development, PTF1 interacts with RBP-Jâ, a key regulator of pancreatic islet development and insulin gene transcription in beta-cells, and, functioning as a transcription factor that regulates the specification of all three pancreatic cell types, suggesting that PTF1 also plays and important role in cerebellar neurogenesis, they cooperate in regulating the expression of PDX-1 (pancreas/duodenum homeobox protein 1), together, &hellip, ¹, PTF1 is a pancreas-specific protein that functions as a component of the trimeric pancreas transcription factor 1 (PTF1) complex |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
PTF1-p48 bHLHa29 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PTF1A Conjugated |
| Short name: |
FITC Conjugated, PTF1A Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, PTF1A (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
23734 |
| Gene: |
PTF1A |
More about : PTF1A |
| Long gene name: |
1a , pancreas specific transcription factor |
| Locus: |
10p12, 2 |
| Discovery year: |
2003-12-04 |
| GenBank acession: |
BK000272 |
| Entrez gene record: |
256297 |
| Pubmed identfication: |
8703005 |
| RefSeq identity: |
NM_178161 |
| Classification: |
Basic helix-loop-helix proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000017815 |