| Long name: |
Biotin Conjugated, DORFIN/RNF19 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
DORFIN/RNF19 |
| Specificity: |
This is a highly specific antibody against DORFIN/RNF19 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human DORFIN/RNF19 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
CaSR and mutant variants of SOD-1, Dorfin functions by accepting ubiquitin in the form of a thioester from UBCH7 and UBC8 and then transferring it to the targeted substrates, Dorfin is responsible for ubiquitylating synphilin-1, Dorfin physically interacts with VCP (Valosin-containing protein) via its C-terminus, E3 ubiquitin-protein ligase, It is widely expressed with highest levels found in heart and ubiquitous expression throughout the central nervous system, RING-IBR type, This association with UBIs suggests that Dorfin plays an important role in the disease process, Together these two proteins are associated with the formation of ubiquitylated inclusions (UBIs) that characterize many neurodegenerative disorders, a protein at fault for familial ALS (amyotrophic lateral sclerosis), such as Parkinsonâ, &euro, &trade, Dorfin is a multi-pass membrane, s disease and ALS |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
dorfin DKFZp566B1346 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
DORFIN/RNF19 Conjugated |
| Short name: |
Conjugated, DORFIN/RNF19 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, DORFIN/RNF19 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
13432 |
| Gene: |
RNF19A |
More about : RNF19A |
| Long gene name: |
RBR E3 ubiquitin protein ligase , ring finger protein 19A |
| Synonyms gene: |
RNF19 |
| Synonyms gene name: |
E3 ubiquitin protein ligase , ring finger protein 19 ring finger protein 19A ring finger protein 19A |
| Locus: |
8q22, 2 |
| Discovery year: |
2003-02-28 |
| GenBank acession: |
AB029316 |
| Entrez gene record: |
25897 |
| Pubmed identfication: |
11237715 10976766 |
| RefSeq identity: |
NM_015435 |
| Classification: |
Ring finger proteins RBR E3 ubiquitin ligases |
| Havana BLAST/BLAT: |
OTTHUMG00000164707 |