| Long name: |
DORFIN/RNF19 Primary Polyclonal Antibody |
| Also known as: |
DORFIN/RNF19 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
DORFIN/RNF19 |
| Specificity: |
This is a highly specific antibody against DORFIN/RNF19 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DORFIN/RNF19 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
CaSR and mutant variants of SOD-1, Dorfin functions by accepting ubiquitin in the form of a thioester from UBCH7 and UBC8 and then transferring it to the targeted substrates, Dorfin is responsible for ubiquitylating synphilin-1, Dorfin physically interacts with VCP (Valosin-containing protein) via its C-terminus, E3 ubiquitin-protein ligase, It is widely expressed with highest levels found in heart and ubiquitous expression throughout the central nervous system, RING-IBR type, This association with UBIs suggests that Dorfin plays an important role in the disease process, Together these two proteins are associated with the formation of ubiquitylated inclusions (UBIs) that characterize many neurodegenerative disorders, a protein at fault for familial ALS (amyotrophic lateral sclerosis), such as Parkinsonâ, &euro, &trade, Dorfin is a multi-pass membrane, s disease and ALS |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
AA032313, DKFZP566B1346, Double ring finger protein, Double ring-finger protein, E3 ubiquitin-protein ligase RNF19A, RING finger protein 19A, RN19A_HUMAN, RNF19, RNF19A, Ring IBR ring domain containing protein Dorfin, Ring finger protein 19, UIP117, Ubce7ip2, XYbp, p38, p38 protein, Dorfin |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
DORFIN/RNF19 |
| Short name: |
DORFIN/RNF19 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
DORFIN/RNF19 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
13432 |
| Gene: |
RNF19A |
More about : RNF19A |
| Long gene name: |
RBR E3 ubiquitin protein ligase , ring finger protein 19A |
| Synonyms gene: |
RNF19 |
| Synonyms gene name: |
E3 ubiquitin protein ligase , ring finger protein 19 ring finger protein 19A ring finger protein 19A |
| Synonyms: |
dorfin DKFZp566B1346 |
| Locus: |
8q22, 2 |
| Discovery year: |
2003-02-28 |
| GenBank acession: |
AB029316 |
| Entrez gene record: |
25897 |
| Pubmed identfication: |
11237715 10976766 |
| RefSeq identity: |
NM_015435 |
| Classification: |
Ring finger proteins RBR E3 ubiquitin ligases |
| Havana BLAST/BLAT: |
OTTHUMG00000164707 |