| Long name: |
ALEXA FLUOR 488 Conjugated, DORFIN/RNF19 Polyclonal Antibody |
| Also known as: |
Anti-DORFIN/RNF19 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
DORFIN/RNF19 |
| Specificity: |
This is a highly specific antibody against DORFIN/RNF19 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DORFIN/RNF19 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
CaSR and mutant variants of SOD-1, Dorfin functions by accepting ubiquitin in the form of a thioester from UBCH7 and UBC8 and then transferring it to the targeted substrates, Dorfin is responsible for ubiquitylating synphilin-1, Dorfin physically interacts with VCP (Valosin-containing protein) via its C-terminus, E3 ubiquitin-protein ligase, It is widely expressed with highest levels found in heart and ubiquitous expression throughout the central nervous system, RING-IBR type, This association with UBIs suggests that Dorfin plays an important role in the disease process, Together these two proteins are associated with the formation of ubiquitylated inclusions (UBIs) that characterize many neurodegenerative disorders, a protein at fault for familial ALS (amyotrophic lateral sclerosis), such as Parkinsonâ, &euro, &trade, Dorfin is a multi-pass membrane, s disease and ALS |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
dorfin DKFZp566B1346 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the DORFIN/RNF19 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
DORFIN/RNF19 |
| Short name: |
DORFIN/RNF19 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, DORFIN/RNF19 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
13432 |
| Gene: |
RNF19A |
More about : RNF19A |
| Long gene name: |
RBR E3 ubiquitin protein ligase , ring finger protein 19A |
| Synonyms gene: |
RNF19 |
| Synonyms gene name: |
E3 ubiquitin protein ligase , ring finger protein 19 ring finger protein 19A ring finger protein 19A |
| Locus: |
8q22, 2 |
| Discovery year: |
2003-02-28 |
| GenBank acession: |
AB029316 |
| Entrez gene record: |
25897 |
| Pubmed identfication: |
11237715 10976766 |
| RefSeq identity: |
NM_015435 |
| Classification: |
Ring finger proteins RBR E3 ubiquitin ligases |
| Havana BLAST/BLAT: |
OTTHUMG00000164707 |