| Long name: |
ALEXA FLUOR 488 Conjugated, DMPK Polyclonal Antibody |
| Also known as: |
Anti-DMPK PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
DMPK |
| Specificity: |
This is a highly specific antibody against DMPK |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DMPK |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
DM arises through expansion of CTG repeats in the 3â, DMPK is implicated in myotonic muscular dystrophy (DM), L-type calcium channels, Mutant DMPK transcripts with an extended region of CUG repeats are retained in the nucleus (5), Other substrates for DMPK include myogenin, These transcripts also influence the expression of the DM locus-associated homeodomain protein (DMAHP)/SIX5, an autosomal dominant-inherited disorder that predominately affects skeletal and cardiac muscle and causes defects in cardiac conduction (2, and Phospholemman (PLM) (1), to mediate in part the DM phenotype (6), &euro, &trade, -UTR of the DMPK gene (4), 3), Myotonic dystrophy protein kinase is a multi-domain protein kinase found in muscle that is activated in response to G protein second messengers and proteolysis (1) |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
DMK DM1PK MDPK MT-PK |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the DMPK Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
DMPK |
| Short name: |
DMPK Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, DMPK (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2933 |
| Gene: |
DMPK |
More about : DMPK |
| Long gene name: |
dystrophia myotonica protein kinase |
| Synonyms gene: |
DM1 DM |
| Synonyms gene name: |
dystrophia myotonica 1 (includes dystrophia myotonia protein kinase) |
| Synonyms name: |
dystrophia myotonica 1 DM protein kinase myotonin protein kinase A myotonic dystrophy associated protein kinase thymopoietin homolog |
| Locus: |
19q13, 32 |
| Discovery year: |
1997-10-10 |
| GenBank acession: |
L19268 |
| Entrez gene record: |
1760 |
| Pubmed identfication: |
1546325 1546326 |
| RefSeq identity: |
NM_004409 |
| Havana BLAST/BLAT: |
OTTHUMG00000182334 |