| Long name: |
Biotin Conjugated, MTMR2 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MTMR2 |
| Specificity: |
This is a highly specific antibody against MTMR2 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human MTMR2 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
MTMR family members hydrolyze both Phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3, MTMR2 interacts with MTMR5, MTMR3 and MTMR4 can either interact with each other or self associate, MTMR6 regulates the activity of the calcium-activated potassium channel 3, MTMR9 regulates the activity of MTMR7 and MTMR8, Mutations in MTMR2 cause autosomal recessive Charcot-Marie-Tooth type 4B1 (CMT4B1), They are protein tyrosine phosphatases that utilize inositol phospholipids, an inactive family member that increases the enzymatic activity of MTMR2 and dictates its subcellular localization, as substrates, focally folded myelin sheaths and demyelination, rather than phosphoproteins, which is characterized by reduced nerve conduction velocities, 1, 5)P2, Myotubularin and the myotubularin-related proteins (MTMR1-9) belong to a highly conserved family of eukaryotic phosphatases |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
KIAA1073 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
MTMR2 Conjugated |
| Short name: |
Conjugated, MTMR2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, MTMR2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7450 |
| Gene: |
MTMR2 |
More about : MTMR2 |
| Long gene name: |
myotubularin related protein 2 |
| Synonyms gene: |
CMT4B |
| Synonyms name: |
phosphatidylinositol-3-phosphatase phosphoinositide-3-phosphatase |
| Locus: |
11q21 |
| Discovery year: |
1999-02-05 |
| GenBank acession: |
U58033 |
| Entrez gene record: |
8898 |
| Pubmed identfication: |
8640223 9736772 |
| RefSeq identity: |
NM_016156 |
| Classification: |
Phosphoinositide phosphatases Myotubularins |
| Havana BLAST/BLAT: |
OTTHUMG00000153837 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_257 |