| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MTMR2 |
| Specificity: |
This antibody reacts specifically with MTMR2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human MTMR2 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
MTMR family members hydrolyze both Phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3, MTMR2 interacts with MTMR5, MTMR3 and MTMR4 can either interact with each other or self associate, MTMR6 regulates the activity of the calcium-activated potassium channel 3, MTMR9 regulates the activity of MTMR7 and MTMR8, Mutations in MTMR2 cause autosomal recessive Charcot-Marie-Tooth type 4B1 (CMT4B1), They are protein tyrosine phosphatases that utilize inositol phospholipids, an inactive family member that increases the enzymatic activity of MTMR2 and dictates its subcellular localization, as substrates, focally folded myelin sheaths and demyelination, rather than phosphoproteins, which is characterized by reduced nerve conduction velocities, 1, 5)P2, Myotubularin and the myotubularin-related proteins (MTMR1-9) belong to a highly conserved family of eukaryotic phosphatases |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KIAA1073 |
| Also known as: |
MTMR2 Polyclonal Antibody |
| Other name: |
Anti-MTMR2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MTMR2 |
| Short name: |
Anti-MTMR2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-MTMR2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
7450 |
| Gene: |
MTMR2 |
More about : MTMR2 |
| Long gene name: |
myotubularin related protein 2 |
| Synonyms gene: |
CMT4B |
| Synonyms name: |
phosphatidylinositol-3-phosphatase phosphoinositide-3-phosphatase |
| Locus: |
11q21 |
| Discovery year: |
1999-02-05 |
| GenBank acession: |
U58033 |
| Entrez gene record: |
8898 |
| Pubmed identfication: |
8640223 9736772 |
| RefSeq identity: |
NM_016156 |
| Classification: |
Phosphoinositide phosphatases Myotubularins |
| Havana BLAST/BLAT: |
OTTHUMG00000153837 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_257 |