| Long name: |
FITC Conjugated, Doppel/DPL Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Doppel/DPL |
| Specificity: |
This is a highly specific antibody against Doppel/DPL |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human Doppel |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
BSE in cattle, Dpl does not appear to contribute to prion disease progression, Dpl is also thought to play a role in angiogenesis, Dpl is characterized by an alpha-helical conformation, Dpl is highly expressed in adult testis and heart and is detectable in the brain of neonatal mice, Infectious PrPSc is highly expressed in the brain of animals affected by TSEs, The PRND gene locus, and Cruetzfeldt-Jacob disease in humans, and it is presented on the cell surface by a glycosylphosphatidylinositol anchor, and two N-linked oligosaccharides, but ectopic expression of Dpl is implicated in neuronal degeneration of ataxic PRP-deficient mice, encodes for the doppel protein (Dpl), including scrapie in sheep, infectious or sporadic, intramolecular disulfide bonds, lethal neurodegenerative disorders involving alterations of the prion protein (PrP), located on human chromosome 20p, specifically maturation of the blood-brain barrier, which exhibits approximately 25% sequence homology with PrP, Prion diseases or transmissible spongiform encephalopathies (TSEs) are manifested as genetic |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
DPL dJ1068H6, 4 DOPPEL PrPLP |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Doppel/DPL Conjugated |
| Short name: |
FITC Conjugated, Doppel/DPL Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, Doppel/DPL (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
15748 |
| Gene: |
PRND |
More about : PRND |
| Long gene name: |
prion like protein doppel |
| Synonyms gene name: |
prion protein 2 (dublet) |
| Synonyms name: |
prion-like protein doppel downstream prion protein-like gene |
| Locus: |
20p13 |
| Discovery year: |
2001-05-30 |
| GenBank acession: |
AF106918 |
| Entrez gene record: |
23627 |
| Pubmed identfication: |
10525406 10577243 |
| RefSeq identity: |
NM_012409 |
| Havana BLAST/BLAT: |
OTTHUMG00000031789 |