Gemin 1/SMA Antibody, ALEXA FLUOR 594

Catalog number:	bs-11561R-A594 Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	Gemin 1/SMA Antibody, ALEXA FLUOR 594
Quantity:	0.1ml
Related search:	sma gemin smn alexa antibody gene antibodies spinal synonyms disease

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Long name:	ALEXA FLUOR 594 Conjugated, Gemin 1/SMA Polyclonal Antibody
Also known as:	Anti-Gemin 1/SMA PAb ALEXA FLUOR 594
Category:	Conjugated Primary Antibodies
Conjugated with:	594, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	Gemin 1/SMA
Specificity:	This is a highly specific antibody against Gemin 1/SMA
Modification:	Unmodified
Modification Site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Source:	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Gemin 1
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	Cytoplasmic SMN interacts with spliceosomal Sm proteins and facilitates their assembly onto U snRNAs, Gemin3 (a DEAD box RNA helicase), Gemin4, Gemin5 and Gemin6, Nearly identical telomeric and centromeric forms of SMN encode the same protein, SMA is caused by deletion or loss-of-function mutations of SMN (survival of motor neuron) gene, SMN, SMN is expresed in a wide variety of tissues including brain, SMN is oligomeric and forms a complex with Gemin2 (formerly SIP1), SMN1, SMNT and BCD541, The SMN complex is found in both the cytoplasm and the nucleus, The SMN complex plays an essential role in splicesomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing of the nucleus, The nuclear form is concentrated in subnuclear bodies called gems (gemini of the coiled bodies), also known as Gemin1, and nuclear SMN mediates recycling of pre-mRNA splicing factors, as well as several spliceosomal snRNP proteins, exists as four isoforms produced by alternative splicing, however, kidney, liver, only mutations in the telomeric form are associated with the disease-state SMA, spinal cord and moderately in skeletal and cardiac muscle, Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of motor neurons in the spinal cord
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	590nm/617nm
Synonyms:	BCD541 SMNT SMA1 SMA2 SMA3 GEMIN1 TDRD16A
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	594, ALEXA FLUOR®, Alexa Fluor
Conjugated:	Alexa conjugate 1
Gene target:	Gemin 1/SMA
Short name:	Gemin 1/SMA Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 594
Alternative name:	ALEXA FLUOR 594, Gemin 1/SMA (Antibody to)
Alternative technique:	antibodies
Identity:	11117
Gene:	SMN1 | More about : SMN1
Long gene name:	survival of motor neuron 1, telomeric
Synonyms gene:	SMA@ SMA
Synonyms gene name:	Kugelberg-Welander disease) , spinal muscular atrophy (Werdnig-Hoffmann disease
Synonyms name:	gemin-1 tudor domain containing 16A
Locus:	5q13, 2
Discovery year:	1996-12-12
GenBank acession:	U18423
Entrez gene record:	6606
Pubmed identfication:	7813012
RefSeq identity:	NM_000344
Classification:	Tudor domain containing
Havana BLAST/BLAT:	OTTHUMG00000099361
Locus Specific Databases:	SMN1 - Spinal Muscular Atrophy (SMA) Leiden Muscular Dystrophy pages ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_676

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