| Long name: |
Gemin 1/SMA Primary Polyclonal Antibody |
| Also known as: |
Gemin 1/SMA PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Gemin 1/SMA |
| Specificity: |
This is a highly specific antibody against Gemin 1/SMA |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Gemin 1 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Cytoplasmic SMN interacts with spliceosomal Sm proteins and facilitates their assembly onto U snRNAs, Gemin3 (a DEAD box RNA helicase), Gemin4, Gemin5 and Gemin6, Nearly identical telomeric and centromeric forms of SMN encode the same protein, SMA is caused by deletion or loss-of-function mutations of SMN (survival of motor neuron) gene, SMN, SMN is expresed in a wide variety of tissues including brain, SMN is oligomeric and forms a complex with Gemin2 (formerly SIP1), SMN1, SMNT and BCD541, The SMN complex is found in both the cytoplasm and the nucleus, The SMN complex plays an essential role in splicesomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing of the nucleus, The nuclear form is concentrated in subnuclear bodies called gems (gemini of the coiled bodies), also known as Gemin1, and nuclear SMN mediates recycling of pre-mRNA splicing factors, as well as several spliceosomal snRNP proteins, exists as four isoforms produced by alternative splicing, however, kidney, liver, only mutations in the telomeric form are associated with the disease-state SMA, spinal cord and moderately in skeletal and cardiac muscle, Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of motor neurons in the spinal cord |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BCD541, Gemin 1, Gemin-1, Gemin1, SMA, SMA 1, SMA 2, SMA 3, SMA 4, SMA1, SMA2, SMA3, SMA4, SMN, SMN 1, SMN-1, SMN1, SMN2, SMNT, SMN_HUMAN, SMN_HUMAN, Survival motor neuron protein, Survival of motor neuron 1, Survival of motor neuron 1 telomeric, T-BCD541, survival of motor neuron 1, telomeric, Component of gems 1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Gemin 1/SMA |
| Short name: |
Gemin 1/SMA Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Gemin 1/SMA (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11117 |
| Gene: |
SMN1 |
More about : SMN1 |
| Long gene name: |
survival of motor neuron 1, telomeric |
| Synonyms gene: |
SMA@ SMA |
| Synonyms gene name: |
Kugelberg-Welander disease) , spinal muscular atrophy (Werdnig-Hoffmann disease |
| Synonyms: |
BCD541 SMNT SMA1 SMA2 SMA3 GEMIN1 TDRD16A |
| Synonyms name: |
gemin-1 tudor domain containing 16A |
| Locus: |
5q13, 2 |
| Discovery year: |
1996-12-12 |
| GenBank acession: |
U18423 |
| Entrez gene record: |
6606 |
| Pubmed identfication: |
7813012 |
| RefSeq identity: |
NM_000344 |
| Classification: |
Tudor domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000099361 |
| Locus Specific Databases: |
SMN1 - Spinal Muscular Atrophy (SMA) Leiden Muscular Dystrophy pages ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_676 |