| Long name: |
Biotin Conjugated, UNC5H3/UNC5C Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
UNC5H3/UNC5C |
| Specificity: |
This is a highly specific antibody against UNC5H3/UNC5C |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
KLH conjugated synthetic peptide derived from human UNC5H3 |
| Tested applications: |
IHC-P |
| Recommended dilutions: |
IHC-P(1:100-500) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Additionally, In the absence of netrin-1, It is also involved in mediating the repulsive action for netrin-1 and it serves as a stop signal for migratory cells, The expression of UNC5H receptors is down-regulated in multiple cancers, This activity is blocked by the binding of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, UNC5H receptors induce apoptosis when cleaved by a caspase, UNC5H3, also known as UNC5C, and kidney cancers, breast, but mutation of these receptors provides a potential mechanism for tumorigenicity, including colorectal, lung, ovary, plays an important role in the development of spinal accessory motor neurons, producing an intracellular fragment containing a death domain, stomach, uterus, The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
Netrin receptor UNC5C, Protein unc 5 homolog C, UNC5C_HUMAN, UNC5H3, Unc 5 homolog 3, Unc 5 homolog C, Unc5 C, elegans transmembrane receptor Unc5, Alternative nameshomolog of C, elegans homolog c |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
UNC5H3/UNC5C Conjugated |
| Short name: |
Conjugated, UNC5H3/UNC5C Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, elegans) (Antibody to), UNC5H3/unc-5 homolog C (C |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Plasma membranes, UNC5C and IDBG-30714 and ENSG00000182168 and 8633, UNC5C and IDBG-640984 and ENSBTAG00000002084 and 533256, UNC5H3, Unc5c and IDBG-196891 and ENSMUSG00000059921 and 22253, elegans), protein binding, this GO :0005042 and netrin receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0007420 and brain development and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0030334 and regulation of cell migration and biological process this GO :0033564 and anterior/posterior axon guidance and biological process this GO :0038007 and netrin-activated signaling pathway and biological process this GO :0043065 and positive regulation of apoptotic process and biological process, this GO :0005042 : netrin receptor activity, this GO :0005042 : netrin receptor activity and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, unc-5 homolog C (C |