| Long name: |
UNC5H3/UNC5C Primary Polyclonal Antibody |
| Also known as: |
UNC5H3/UNC5C PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
UNC5H3/UNC5C |
| Specificity: |
This is a highly specific antibody against UNC5H3/UNC5C |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human UNC5H3 |
| Tested Applications: |
IF(IHC-P), IHC-P, FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), FCM(1:20-100) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Additionally, In the absence of netrin-1, It is also involved in mediating the repulsive action for netrin-1 and it serves as a stop signal for migratory cells, The expression of UNC5H receptors is down-regulated in multiple cancers, This activity is blocked by the binding of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, UNC5H receptors induce apoptosis when cleaved by a caspase, UNC5H3, also known as UNC5C, and kidney cancers, breast, but mutation of these receptors provides a potential mechanism for tumorigenicity, including colorectal, lung, ovary, plays an important role in the development of spinal accessory motor neurons, producing an intracellular fragment containing a death domain, stomach, uterus, The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Netrin receptor UNC5C, Protein unc 5 homolog C, UNC5C_HUMAN, UNC5H3, Unc 5 homolog 3, Unc 5 homolog C, Unc5 C, elegans transmembrane receptor Unc5, Alternative nameshomolog of C, elegans homolog c |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
UNC5H3/UNC5C |
| Short name: |
UNC5H3/UNC5C Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
elegans) (Antibody to), UNC5H3/unc-5 homolog C (C |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Plasma membranes, UNC5C and IDBG-30714 and ENSG00000182168 and 8633, UNC5C and IDBG-640984 and ENSBTAG00000002084 and 533256, UNC5H3, Unc5c and IDBG-196891 and ENSMUSG00000059921 and 22253, elegans), protein binding, this GO :0005042 and netrin receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0007420 and brain development and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0030334 and regulation of cell migration and biological process this GO :0033564 and anterior/posterior axon guidance and biological process this GO :0038007 and netrin-activated signaling pathway and biological process this GO :0043065 and positive regulation of apoptotic process and biological process, this GO :0005042 : netrin receptor activity, this GO :0005042 : netrin receptor activity and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, unc-5 homolog C (C |