| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
UNC5H3/UNC5C |
| Specificity: |
This antibody reacts specifically with UNC5H3/UNC5C |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human UNC5H3 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Additionally, In the absence of netrin-1, It is also involved in mediating the repulsive action for netrin-1 and it serves as a stop signal for migratory cells, The expression of UNC5H receptors is down-regulated in multiple cancers, This activity is blocked by the binding of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, UNC5H receptors induce apoptosis when cleaved by a caspase, UNC5H3, also known as UNC5C, and kidney cancers, breast, but mutation of these receptors provides a potential mechanism for tumorigenicity, including colorectal, lung, ovary, plays an important role in the development of spinal accessory motor neurons, producing an intracellular fragment containing a death domain, stomach, uterus, The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Netrin receptor UNC5C, Protein unc 5 homolog C, UNC5C_HUMAN, UNC5H3, Unc 5 homolog 3, Unc 5 homolog C, Unc5 C, elegans transmembrane receptor Unc5, Alternative nameshomolog of C, elegans homolog c |
| Also known as: |
UNC5H3/UNC5C Polyclonal Antibody |
| Other name: |
Anti-UNC5H3/UNC5C Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
UNC5H3/UNC5C |
| Short name: |
Anti-UNC5H3/UNC5C (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, elegans) (polyclonal), antibody to-UNC5H3/unc-5 homolog C (C |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
Plasma membranes, UNC5C and IDBG-30714 and ENSG00000182168 and 8633, UNC5C and IDBG-640984 and ENSBTAG00000002084 and 533256, UNC5H3, Unc5c and IDBG-196891 and ENSMUSG00000059921 and 22253, elegans), protein binding, this GO :0005042 and netrin receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0007420 and brain development and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0030334 and regulation of cell migration and biological process this GO :0033564 and anterior/posterior axon guidance and biological process this GO :0038007 and netrin-activated signaling pathway and biological process this GO :0043065 and positive regulation of apoptotic process and biological process, this GO :0005042 : netrin receptor activity, this GO :0005042 : netrin receptor activity and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, unc-5 homolog C (C |