| Long name: |
Biotin Conjugated, UNC5B/UNC5H2 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
UNC5B/UNC5H2 |
| Specificity: |
This is a highly specific antibody against UNC5B/UNC5H2 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
KLH conjugated synthetic peptide derived from human UNC5B |
| Tested applications: |
IHC-P |
| Recommended dilutions: |
IHC-P(1:100-500) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Additionally, Hence, In fact, The expression of UNC5H receptors is down-regulated in multiple cancers, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, UNC5H receptors express widely in cells that migrate, UNC5H receptors induce apoptosis when cleaved by a caspase, UNC5H2, also designated unc-5 homolog B or p53-regulated receptor for death and life protein 1 (p53RDL1) is highly expressed in brain with lower levels of expression observed in developing lung, and kidney cancers, breast, but mutation of these receptors provides a potential mechanism for tumorigenicity, but this activity is blocked by the binding of netrin-1, cartilage, in the absence of netrin-1, including colorectal, kidney and hematopoietic and immune tissues, lung, ovary, producing an intracellular fragment containing a death domain, stomach, uterus, where they bind the G protein G Alpha 1-2 to inhibit G protein signaling, The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
UNC5H2 p53RDL1 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
UNC5B/UNC5H2 Conjugated |
| Short name: |
Conjugated, UNC5B/UNC5H2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, elegans)/UNC5H2 (Antibody to), unc-5 homolog B (C |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Plasma membranes, UNC5B and IDBG-629823 and ENSBTAG00000014270 and 100851524, UNC5B and IDBG-77562 and ENSG00000107731 and 219699, Unc5b and IDBG-154989 and ENSMUSG00000020099 and 107449, elegans), protein binding, this GO :0005515 and protein binding and molecular function this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0014068 and positive regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0033564 and anterior/posterior axon guidance and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :2001240 and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, 524942, unc-5 homolog B (C |
| Identity: |
12568 |
| Gene: |
UNC5B |
More about : UNC5B |
| Long gene name: |
unc-5 netrin receptor B |
| Synonyms gene name: |
elegans) , unc5 (C, elegans homolog) b unc-5 homolog B (C |
| Locus: |
10q22, 1 |
| Discovery year: |
1998-12-09 |
| GenBank acession: |
AB096256 |
| Entrez gene record: |
219699 |
| Pubmed identfication: |
12655055 20693423 |
| RefSeq identity: |
NM_170744 |
| Classification: |
I-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000018422 |