| Long name: |
UNC5B/UNC5H2 Primary Polyclonal Antibody |
| Also known as: |
UNC5B/UNC5H2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
UNC5B/UNC5H2 |
| Specificity: |
This is a highly specific antibody against UNC5B/UNC5H2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human UNC5B |
| Tested Applications: |
IF(IHC-P), IHC-P |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Additionally, Hence, In fact, The expression of UNC5H receptors is down-regulated in multiple cancers, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, UNC5H receptors express widely in cells that migrate, UNC5H receptors induce apoptosis when cleaved by a caspase, UNC5H2, also designated unc-5 homolog B or p53-regulated receptor for death and life protein 1 (p53RDL1) is highly expressed in brain with lower levels of expression observed in developing lung, and kidney cancers, breast, but mutation of these receptors provides a potential mechanism for tumorigenicity, but this activity is blocked by the binding of netrin-1, cartilage, in the absence of netrin-1, including colorectal, kidney and hematopoietic and immune tissues, lung, ovary, producing an intracellular fragment containing a death domain, stomach, uterus, where they bind the G protein G Alpha 1-2 to inhibit G protein signaling, The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Netrin receptor UNC5B Precursor, Protein XUNC 5, Protein unc-5 homolog 2, Protein unc-5 homolog B, Transmembrane receptor Unc5H2, UNC 5B, UNC5B_HUMAN, UNC5H2, Unc 5 homolog 2, Unc 5 homolog B, Unc5 C, Unc5b, p53 regulated receptor for death and le, p53 regulated receptor for death and le protein 1, p53-regulated receptor for death and le protein 1, p53RDL1, Netrin receptor UNC5B, elegans homolog b |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
UNC5B/UNC5H2 |
| Short name: |
UNC5B/UNC5H2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
elegans)/UNC5H2 (Antibody to), unc-5 homolog B (C |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Plasma membranes, UNC5B and IDBG-629823 and ENSBTAG00000014270 and 100851524, UNC5B and IDBG-77562 and ENSG00000107731 and 219699, Unc5b and IDBG-154989 and ENSMUSG00000020099 and 107449, elegans), protein binding, this GO :0005515 and protein binding and molecular function this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0014068 and positive regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0033564 and anterior/posterior axon guidance and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :2001240 and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, 524942, unc-5 homolog B (C |
| Identity: |
12568 |
| Gene: |
UNC5B |
More about : UNC5B |
| Long gene name: |
unc-5 netrin receptor B |
| Synonyms gene name: |
elegans) , unc5 (C, elegans homolog) b unc-5 homolog B (C |
| Synonyms: |
UNC5H2 p53RDL1 |
| Locus: |
10q22, 1 |
| Discovery year: |
1998-12-09 |
| GenBank acession: |
AB096256 |
| Entrez gene record: |
219699 |
| Pubmed identfication: |
12655055 20693423 |
| RefSeq identity: |
NM_170744 |
| Classification: |
I-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000018422 |