| Long name: |
ALEXA FLUOR 647 Conjugated, UNC5B/UNC5H2 Polyclonal Antibody |
| Also known as: |
Anti-UNC5B/UNC5H2 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
UNC5B/UNC5H2 |
| Specificity: |
This is a highly specific antibody against UNC5B/UNC5H2 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human UNC5B |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Additionally, Hence, In fact, The expression of UNC5H receptors is down-regulated in multiple cancers, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, UNC5H receptors express widely in cells that migrate, UNC5H receptors induce apoptosis when cleaved by a caspase, UNC5H2, also designated unc-5 homolog B or p53-regulated receptor for death and life protein 1 (p53RDL1) is highly expressed in brain with lower levels of expression observed in developing lung, and kidney cancers, breast, but mutation of these receptors provides a potential mechanism for tumorigenicity, but this activity is blocked by the binding of netrin-1, cartilage, in the absence of netrin-1, including colorectal, kidney and hematopoietic and immune tissues, lung, ovary, producing an intracellular fragment containing a death domain, stomach, uterus, where they bind the G protein G Alpha 1-2 to inhibit G protein signaling, The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
UNC5H2 p53RDL1 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the UNC5B/UNC5H2 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
UNC5B/UNC5H2 |
| Short name: |
UNC5B/UNC5H2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, elegans)/UNC5H2 (Antibody to), unc-5 homolog B (C |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Plasma membranes, UNC5B and IDBG-629823 and ENSBTAG00000014270 and 100851524, UNC5B and IDBG-77562 and ENSG00000107731 and 219699, Unc5b and IDBG-154989 and ENSMUSG00000020099 and 107449, elegans), protein binding, this GO :0005515 and protein binding and molecular function this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0014068 and positive regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0033564 and anterior/posterior axon guidance and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :2001240 and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, 524942, unc-5 homolog B (C |
| Identity: |
12568 |
| Gene: |
UNC5B |
More about : UNC5B |
| Long gene name: |
unc-5 netrin receptor B |
| Synonyms gene name: |
elegans) , unc5 (C, elegans homolog) b unc-5 homolog B (C |
| Locus: |
10q22, 1 |
| Discovery year: |
1998-12-09 |
| GenBank acession: |
AB096256 |
| Entrez gene record: |
219699 |
| Pubmed identfication: |
12655055 20693423 |
| RefSeq identity: |
NM_170744 |
| Classification: |
I-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000018422 |