| Long name: |
Synaptic Ras-GAP 1 Primary Polyclonal Antibody |
| Also known as: |
Synaptic Ras-GAP 1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
SynGAP |
| Specificity: |
This is a highly specific antibody against SynGAP |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Synaptic Ras-GAP 1/SynGAP |
| Gene ID number: |
8831 |
| Tested Applications: |
IF(IHC-P), IHC-P |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
It represents one of three classes of mammalian RasGAPs and is specifically localized to excitatory synapses possessing NMDA receptors, Its activity is inhibited by phosphorylation by CaMKII, SynGAP (for synaptic GTPase activating protein), SynGAP interacts with all three PDZ domains within PSD-95/ SAP 90 proteins, SynGAP may be involved in the regulation of BDNF as well as Ras signaling, a novel synaptic RasGAP, are involved in the organization of synaptic structure, hippocampus and olfactory bulb, is a brain-specific protein abundant in the cortex, which are known to bind to and cluster various membrane proteins, which could result in the activation of the MAP kinase pathway, The PSD-95/SAP 90 family of proteins |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
DKFZp761G1421, KIAA1938, MRD5, OTTHUMP00000064825, RASA 1, RASA 5, RASA1, RASA5, Ras GTPase activating protein SynGAP, Ras GTPase-activating protein SynGAP, SYGP1_HUMAN, SYNGAP 1, SYNGAP1, SYNGAP1, Synaptic Ras GAP 1, Synaptic Ras GTPase activating protein 1, Synaptic Ras GTPase activating protein 1 homolog, Synaptic Ras GTPase activating protein 135kDa, Synaptic Ras GTPase-activating protein 1, Synaptic Ras-GAP 1, p135 SynGAP, synaptic Ras GTPase activating protein, Neuronal RasGAP |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Synaptic Ras-GAP 1 |
| Short name: |
Synaptic Ras-GAP 1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Synaptic Ras-GAP 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9871 |
| Gene: |
RASA1 |
More about : RASA1 |
| Long gene name: |
RAS p21 protein activator 1 |
| Synonyms gene: |
RASA |
| Synonyms gene name: |
RAS p21 protein activator (GTPase activating protein) 1 |
| Synonyms: |
GAP CM-AVM p120GAP p120RASGAP p120 |
| Synonyms name: |
capillary malformation-arteriovenous malformation p120 RAS GTPase activating protein |
| Locus: |
5q14, 3 |
| Discovery year: |
1989-06-30 |
| Entrez gene record: |
5921 |
| Pubmed identfication: |
15917201 |
| RefSeq identity: |
NM_002890 |
| Classification: |
Pleckstrin homology domain containing SH2 domain containing C2 and RasGAP domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000162605 |
| Locus Specific Databases: |
SH2base: Database for pathogenic SH2 domain mutations |