| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SynGAP |
| Specificity: |
This antibody reacts specifically with Synaptic Ras-GAP 1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Synaptic Ras-GAP 1/SynGAP |
| Gene ID: |
8831 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
It represents one of three classes of mammalian RasGAPs and is specifically localized to excitatory synapses possessing NMDA receptors, Its activity is inhibited by phosphorylation by CaMKII, SynGAP (for synaptic GTPase activating protein), SynGAP interacts with all three PDZ domains within PSD-95/ SAP 90 proteins, SynGAP may be involved in the regulation of BDNF as well as Ras signaling, a novel synaptic RasGAP, are involved in the organization of synaptic structure, hippocampus and olfactory bulb, is a brain-specific protein abundant in the cortex, which are known to bind to and cluster various membrane proteins, which could result in the activation of the MAP kinase pathway, The PSD-95/SAP 90 family of proteins |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
GAP CM-AVM p120GAP p120RASGAP p120 |
| Also known as: |
Synaptic Ras-GAP 1 Polyclonal Antibody |
| Other name: |
Anti-Synaptic Ras-GAP 1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Synaptic Ras-GAP 1 |
| Short name: |
Anti-Synaptic Ras-GAP 1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Synaptic Ras-GAP 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
9871 |
| Gene: |
RASA1 |
More about : RASA1 |
| Long gene name: |
RAS p21 protein activator 1 |
| Synonyms gene: |
RASA |
| Synonyms gene name: |
RAS p21 protein activator (GTPase activating protein) 1 |
| Synonyms name: |
capillary malformation-arteriovenous malformation p120 RAS GTPase activating protein |
| Locus: |
5q14, 3 |
| Discovery year: |
1989-06-30 |
| Entrez gene record: |
5921 |
| Pubmed identfication: |
15917201 |
| RefSeq identity: |
NM_002890 |
| Classification: |
Pleckstrin homology domain containing SH2 domain containing C2 and RasGAP domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000162605 |
| Locus Specific Databases: |
SH2base: Database for pathogenic SH2 domain mutations |