| Long name: |
Biotin Conjugated, PTPN5/STEP Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PTPN5/STEP |
| Specificity: |
This is a highly specific antibody against PTPN5/STEP |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human PTPN5 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Isolated from mouse brain, STEP depresses both NMDAR single-channel activity and synaptic currents, STEP family members are expressed in the dopaminoceptive neurons of the CNS, STEP61 contains a single tyrosine phosphatase domain, STEP61 dephosphorylates Tyr-420 residue and may thus regulate Fyn activity in PSDs, The STEP protein regulates the N-methyl-d-aspartate receptor (NMDAR) complex, The STEP61 protein associates with the Src family kinase member Fyn when Fyn is phosphorylated at Tyr-420 and not Tyr-431, The human STEP gene maps to chromosome 11p15, The membrane-associated STEP61 isoform localizes in the postsynaptic densities (PSDs) of striatal neurons, Upon association, the STEP20 isoform lacks the conserved tyrosine phosphatase domain, two proline-rich domains and two transmembrane domains, with highest expression in the basal ganglia and related structures, 1, 2-p15, The brain-specific STEP (striatal enriched phosphatase) family of protein tyrosine phosphatases (PTPs) comprises both transmembrane and cytosolic protein members which are the products of alternative splicing |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
STEP PTPSTEP STEP61 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PTPN5/ Conjugated |
| Short name: |
Conjugated, PTPN5/STEP Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, PTPN5/STEP (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9657 |
| Gene: |
PTPN5 |
More about : PTPN5 |
| Long gene name: |
non-receptor type 5 , protein tyrosine phosphatase |
| Synonyms gene name: |
non-receptor type 5 (striatum-enriched) , protein tyrosine phosphatase |
| Synonyms name: |
striatal-enriched protein tyrosine phosphatase |
| Locus: |
11p15, 1 |
| Discovery year: |
1992-02-12 |
| GenBank acession: |
BC064807 |
| Entrez gene record: |
84867 |
| Pubmed identfication: |
1714595 |
| RefSeq identity: |
NM_001039970 |
| Classification: |
Protein tyrosine phosphatases, non-receptor type |
| Havana BLAST/BLAT: |
OTTHUMG00000134304 |