| Long name: |
Cy3 Conjugated, PTPN5/STEP Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
cy3 conjugation kit |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PTPN5/STEP |
| Specificity: |
This is a highly specific antibody against PTPN5/STEP |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human PTPN5 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Isolated from mouse brain, STEP depresses both NMDAR single-channel activity and synaptic currents, STEP family members are expressed in the dopaminoceptive neurons of the CNS, STEP61 contains a single tyrosine phosphatase domain, STEP61 dephosphorylates Tyr-420 residue and may thus regulate Fyn activity in PSDs, The STEP protein regulates the N-methyl-d-aspartate receptor (NMDAR) complex, The STEP61 protein associates with the Src family kinase member Fyn when Fyn is phosphorylated at Tyr-420 and not Tyr-431, The human STEP gene maps to chromosome 11p15, The membrane-associated STEP61 isoform localizes in the postsynaptic densities (PSDs) of striatal neurons, Upon association, the STEP20 isoform lacks the conserved tyrosine phosphatase domain, two proline-rich domains and two transmembrane domains, with highest expression in the basal ganglia and related structures, 1, 2-p15, The brain-specific STEP (striatal enriched phosphatase) family of protein tyrosine phosphatases (PTPs) comprises both transmembrane and cytosolic protein members which are the products of alternative splicing |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
512, 550nm/570, 615nm |
| Synonyms: |
STEP PTPSTEP STEP61 |
| Properties: |
1 of the PTPN5/STEP Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PTPN5/ Conjugated |
| Short name: |
Conjugated, PTPN5/STEP Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy3 |
| Alternative name: |
cyanine 3 coupled, PTPN5/STEP (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9657 |
| Gene: |
PTPN5 |
More about : PTPN5 |
| Long gene name: |
non-receptor type 5 , protein tyrosine phosphatase |
| Synonyms gene name: |
non-receptor type 5 (striatum-enriched) , protein tyrosine phosphatase |
| Synonyms name: |
striatal-enriched protein tyrosine phosphatase |
| Locus: |
11p15, 1 |
| Discovery year: |
1992-02-12 |
| GenBank acession: |
BC064807 |
| Entrez gene record: |
84867 |
| Pubmed identfication: |
1714595 |
| RefSeq identity: |
NM_001039970 |
| Classification: |
Protein tyrosine phosphatases, non-receptor type |
| Havana BLAST/BLAT: |
OTTHUMG00000134304 |