| Long name: |
FKBP51 Primary Polyclonal Antibody |
| Also known as: |
FKBP51 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
FKBP51 |
| Specificity: |
This is a highly specific antibody against FKBP51 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FKBP51 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
FK506 and rapamycin (1), FKBP12, FKBP51 and FKBP52, FKBP51 and FKBP52 are two highly related proteins (5, FKBP51 is predominantly expressed in T cells and is induced by glucocorticoids (5), FKBP51 mediates the effects of FK506 and rapamycin by inhibiting intracellular calcineurin activity, FKBP52, Several related immunophilins, The ubiquitously expressed FKBP12 also associates with the cytoplasmic domain of the TGF?type I receptor, and by blocking T-cell activation and proliferation (7), and following ligand binding, are characterized as cytosolic FK506-binding proteins, is expressed in a variety of tissues and can also associate with the heat shock protein (hsp90) in mature steroid receptor complexes (6, known also as FKBP-59 or heat shock protein 56, such as cyclosporin, they functionally inhibit the phosphatase activity of calcineurin (2, where it stabilizes the inactive conformation of the receptor and blocks the activation of the TGF?pathway (4), 3), 6), 8), The immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases that bind to and mediate the effects of immunosuppressive drugs |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
51 kDa FK506 binding protein, 51 kDa FK506 binding protein 5, 51 kDa FK506-binding protein, 51 kDa FKBP, 54 kDa progesterone receptor associated immunophilin, 54 kDa progesterone receptor-associated immunophilin, AIG 6, AIG6, Androgen regulated protein 6, Androgen-regulated protein 6, FF1 antigen, FK506 binding protein 5, FK506-binding protein 5, FKBP 51, FKBP 54, FKBP-5, FKBP-51, FKBP5, FKBP54, FKBP5_HUMAN, HSP90 binding immunophilin, HSP90-binding immunophilin, MGC111006, OTTHUMP00000016268, P54 antibody Peptidyl prolyl cis trans isomerase, PPIase, PPIase FKBP5, Peptidyl-prolyl cis-trans isomerase FKBP5, Peptidylprolyl cis trans isomerase, Ptg 10, Ptg10, Rotamase, T cell FK506 binding protein, FKBP 5 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
FKBP51 |
| Short name: |
FKBP51 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
FKBP51 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3721 |
| Gene: |
FKBP5 |
More about : FKBP5 |
| Long gene name: |
FK506 binding protein 5 |
| Synonyms gene name: |
FK506-binding protein 5 |
| Synonyms: |
FKBP51 FKBP54 PPIase P54 Ptg-10 |
| Locus: |
6p21, 31 |
| Discovery year: |
1997-06-09 |
| GenBank acession: |
U42031 |
| Entrez gene record: |
2289 |
| Pubmed identfication: |
9001212 |
| Classification: |
FKBP prolyl isomerases Tetratricopeptide repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000014576 |