| Long name: |
Lefty Primary Polyclonal Antibody |
| Also known as: |
Lefty PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Lefty |
| Specificity: |
This is a highly specific antibody against Lefty |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Lefty |
| Gene ID number: |
10637 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Cleavage is therefore an essential step for Lefty activation, Complexes formed move into the nucleus, Lefty, Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF beta receptor, Lefty also inhibits events downstream from R Smad phosphorylation, Lefty is synthesized as a large inactive precursor (41 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms), Lefty provides a repressed state of TGF beta responsive genes, Members of the TGF beta superfamily require processing for their activation, Secreted growth factors of the TGF beta family, TGF beta (Transforming growth factor beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells, TGF beta actions are directed by ligand induced activation of TGF beta receptors, The 28kDa form induces MAPK activity, The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, a left right axis is established, a novel member of the TGF beta superfamily, and Lefty A and Lefty B in humans, including gene products derived from nodal, inhibits TGF beta signaling, lefty 1 and lefty 2, play crucial roles in establishing left right asymmetries, where they act as components of a transcriptional complex, During vertebrate embryogenesis |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
AI450052, Ebaf, FACTOR B, HOMOLOG OF antibody, LEFT-RIGHT DETERMINATION, LEFT-RIGHT DETERMINATION FACTOR 1, LEFTB, LEFTY 1, LEFTY B, LEFTY1, LEFTY1, LEFTY1, LEFTYB, Left right determination factor 1, Left right determination factor B, Lefty, MOUSE, Protein lefty-B, RGD1561867, STRA3, Stimulated by retinoic acid gene 3 protein, TGF beta 4, TGF-beta-4, Tgfb4, Transforming growth factor beta 4, Transforming growth factor beta-4, factor B, left right determination factor, left-right determination, left-right determination factor, lefty-1, Protein lefty-1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Lefty |
| Short name: |
Lefty Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Lefty (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11770 |
| Gene: |
TGFB4 |
More about : TGFB4 |
| Long gene name: |
left-right determination factor 2 |
| Synonyms gene: |
EBAF |
| Synonyms gene name: |
endometrial bleeding associated factor (left-right determination, factor A, transforming growth factor beta superfamily) |
| Synonyms: |
LEFTA LEFTYA LEFTY2 |
| Synonyms name: |
LEFTY A) , beta-4 (endometrial bleeding-associated factor, transforming growth factor |
| Locus: |
1q42, 12 |
| Discovery year: |
1998-01-20 |
| GenBank acession: |
U81523 |
| Entrez gene record: |
7044 |
| Pubmed identfication: |
9153275 |
| RefSeq identity: |
NM_003240 |
| Havana BLAST/BLAT: |
OTTHUMG00000037441 |