| Long name: |
ALEXA FLUOR 647 Conjugated, Lefty Polyclonal Antibody |
| Also known as: |
Anti-Lefty PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Lefty |
| Specificity: |
This is a highly specific antibody against Lefty |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Lefty |
| Gene ID Number: |
10637 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Cleavage is therefore an essential step for Lefty activation, Complexes formed move into the nucleus, Lefty, Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF beta receptor, Lefty also inhibits events downstream from R Smad phosphorylation, Lefty is synthesized as a large inactive precursor (41 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms), Lefty provides a repressed state of TGF beta responsive genes, Members of the TGF beta superfamily require processing for their activation, Secreted growth factors of the TGF beta family, TGF beta (Transforming growth factor beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells, TGF beta actions are directed by ligand induced activation of TGF beta receptors, The 28kDa form induces MAPK activity, The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, a left right axis is established, a novel member of the TGF beta superfamily, and Lefty A and Lefty B in humans, including gene products derived from nodal, inhibits TGF beta signaling, lefty 1 and lefty 2, play crucial roles in establishing left right asymmetries, where they act as components of a transcriptional complex, During vertebrate embryogenesis |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
LEFTA LEFTYA LEFTY2 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the Lefty Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
Lefty |
| Short name: |
Lefty Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, Lefty (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11770 |
| Gene: |
TGFB4 |
More about : TGFB4 |
| Long gene name: |
left-right determination factor 2 |
| Synonyms gene: |
EBAF |
| Synonyms gene name: |
endometrial bleeding associated factor (left-right determination, factor A, transforming growth factor beta superfamily) |
| Synonyms name: |
LEFTY A) , beta-4 (endometrial bleeding-associated factor, transforming growth factor |
| Locus: |
1q42, 12 |
| Discovery year: |
1998-01-20 |
| GenBank acession: |
U81523 |
| Entrez gene record: |
7044 |
| Pubmed identfication: |
9153275 |
| RefSeq identity: |
NM_003240 |
| Havana BLAST/BLAT: |
OTTHUMG00000037441 |