| Long name: |
ALEXA FLUOR 647 Conjugated, NSMase2 Polyclonal Antibody |
| Also known as: |
Anti-NSMase2 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
NSMase2 |
| Specificity: |
This is a highly specific antibody against NSMase2 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NSMase2 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Expression of N-SMase2 is upregulated during the G0/G1 phases of the cell cycle and optimal N-SMase2 activity occurs at a slightly basic pH of 7, Localized to the membrane of the Golgi apparatus, N-SMase2 deficiency is the cause of chondrodysplasia, N-SMase2 functions to catalyze the hydrolysis of sphingomyelin to form ceramide and phosphocholineâ, N-SMase2 is enzymatically activated by unsaturated fatty acids and phosphatidylserine and, a genetic disorder characterized by impaired bone growth that leads to short stature, also known as NSMASE2 or SMPD3 (sphingomyelin phosphodiesterase 3), bowlegs and underdeveloped joints, is a ubiquitously expressed 655 amino acid member of the magnesium-dependent phosphohydrolase protein family, is involved in growth suppression and postnatal development, through regulation of ceramide synthesis, &euro, &rdquo, 5, N-SMase2 (neutral sphingomyelinase 2), two proteins that mediate cell growth arrest and apoptosis |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
NSMASE2 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the NSMase2 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
NSMase2 |
| Short name: |
NSMase2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, NSMase2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
14240 |
| Gene: |
SMPD3 |
More about : SMPD3 |
| Long gene name: |
sphingomyelin phosphodiesterase 3 |
| Synonyms gene name: |
neutral membrane (neutral sphingomyelinase II) , sphingomyelin phosphodiesterase 3 |
| Synonyms name: |
neutral sphingomyelinase II |
| Locus: |
16q22, 1 |
| Discovery year: |
2000-12-12 |
| GenBank acession: |
AJ250460 |
| Entrez gene record: |
55512 |
| Pubmed identfication: |
10823942 |
| RefSeq identity: |
NM_018667 |
| Havana BLAST/BLAT: |
OTTHUMG00000137559 |