| Long name: |
NSMase2 Primary Polyclonal Antibody |
| Also known as: |
NSMase2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
NSMase2 |
| Specificity: |
This is a highly specific antibody against NSMase2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NSMase2 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Expression of N-SMase2 is upregulated during the G0/G1 phases of the cell cycle and optimal N-SMase2 activity occurs at a slightly basic pH of 7, Localized to the membrane of the Golgi apparatus, N-SMase2 deficiency is the cause of chondrodysplasia, N-SMase2 functions to catalyze the hydrolysis of sphingomyelin to form ceramide and phosphocholineâ, N-SMase2 is enzymatically activated by unsaturated fatty acids and phosphatidylserine and, a genetic disorder characterized by impaired bone growth that leads to short stature, also known as NSMASE2 or SMPD3 (sphingomyelin phosphodiesterase 3), bowlegs and underdeveloped joints, is a ubiquitously expressed 655 amino acid member of the magnesium-dependent phosphohydrolase protein family, is involved in growth suppression and postnatal development, through regulation of ceramide synthesis, &euro, &rdquo, 5, N-SMase2 (neutral sphingomyelinase 2), two proteins that mediate cell growth arrest and apoptosis |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Cca1, Confluent 3Y1 cell-associated protein 1, NSMA2_HUMAN, Neutral sphingomyelinase 2, Neutral sphingomyelinase II, Smpd3, Sphingomyelin phosphodiesterase 3, nSMase-2, nSMase2, neutral sphingomyelinase 2, N-SMase2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
NSMase2 |
| Short name: |
NSMase2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
NSMase2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
14240 |
| Gene: |
SMPD3 |
More about : SMPD3 |
| Long gene name: |
sphingomyelin phosphodiesterase 3 |
| Synonyms gene name: |
neutral membrane (neutral sphingomyelinase II) , sphingomyelin phosphodiesterase 3 |
| Synonyms: |
NSMASE2 |
| Synonyms name: |
neutral sphingomyelinase II |
| Locus: |
16q22, 1 |
| Discovery year: |
2000-12-12 |
| GenBank acession: |
AJ250460 |
| Entrez gene record: |
55512 |
| Pubmed identfication: |
10823942 |
| RefSeq identity: |
NM_018667 |
| Havana BLAST/BLAT: |
OTTHUMG00000137559 |