| Long name: |
Cy7 Conjugated, DAB2 (Ser24) Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy7 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
DAB2 Ser24 |
| Specificity: |
This is a highly specific antibody against DAB2 Ser24 |
| Modification: |
Phosphorylation |
| Modification site: |
Ser24 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human DAB2 around the phosphorylation site of Ser24 [AP(p-S)KK] |
| Gene ID number: |
1601 |
| Swiss Prot: |
P98082 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Can bind and assemble clathrin, Can function in clathrin-mediated endocytosis independently of the AP-2 complex, EPS15L1 and ITSN1, Involved in CFTR trafficking to the late endosome, Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2, Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR, Involved in endocytosis of integrin beta-1, Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development, Involved in several receptor-mediated signaling pathways, May activate non-canonical Wnt signaling, May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1), Mediates TFG-beta-stimulated JNK activation, Required for recycling of the TGF-beta receptor, Sequesters LRP6 towards clathrin-mediated endocytosis, and binds simultaneously to phosphatidylinositol 4, leading to inhibition of Wnt/beta-catenin signaling, such as the LDL receptor, this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, to recruit them to clathrin-coated pits, 5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, 5-bisphosphate (PtdIns(4, Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
743nm/767nm |
| Synonyms: |
DOC-2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths |
| Gene target: |
DAB2 (Ser24) Conjugated |
| Short name: |
Conjugated, DAB2 (Ser24) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy7 |
| Alternative name: |
cyanine 7 coupled, DAB2 (Ser24) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2662 |
| Gene: |
DAB2 |
More about : DAB2 |
| Long gene name: |
DAB2, clathrin adaptor protein |
| Synonyms gene name: |
disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein) disabled homolog 2, homolog 2 (Drosophila) , mitogen-responsive phosphoprotein, mitogen-responsive phosphoprotein (Drosophila) Dab |
| Locus: |
5p13, 1 |
| Discovery year: |
1998-07-29 |
| GenBank acession: |
U53446 |
| Entrez gene record: |
1601 |
| Pubmed identfication: |
8660969 9620555 |
| RefSeq identity: |
NM_001343 |
| Havana BLAST/BLAT: |
OTTHUMG00000162043 |