DAB2 (Ser24) Antibody, ALEXA FLUOR 647

Catalog number:	bs-11044R-A647 Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	DAB2 (Ser24) Antibody, ALEXA FLUOR 647
Quantity:	100ul
Related search:	dab fluor ser antibody endocytosis involved protein receptor phosphoprotein

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Long name:	ALEXA FLUOR 647 Conjugated, DAB2 (Ser24) Polyclonal Antibody
Also known as:	Anti-DAB2 Ser24 PAb ALEXA FLUOR 647
Category:	Conjugated Primary Antibodies
Conjugated with:	647, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	DAB2 Ser24
Specificity:	This is a highly specific antibody against DAB2 Ser24
Modification:	Phosphorylation
Modification Site:	Ser24
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Subcellular location:	Cytoplasm
Source:	KLH conjugated synthetic phosphopeptide derived from human DAB2 around the phosphorylation site of Ser24 [AP(p-S)KK]
Gene ID Number:	1601
Swiss Prot:	P98082
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	Can bind and assemble clathrin, Can function in clathrin-mediated endocytosis independently of the AP-2 complex, EPS15L1 and ITSN1, Involved in CFTR trafficking to the late endosome, Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2, Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR, Involved in endocytosis of integrin beta-1, Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development, Involved in several receptor-mediated signaling pathways, May activate non-canonical Wnt signaling, May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1), Mediates TFG-beta-stimulated JNK activation, Required for recycling of the TGF-beta receptor, Sequesters LRP6 towards clathrin-mediated endocytosis, and binds simultaneously to phosphatidylinositol 4, leading to inhibition of Wnt/beta-catenin signaling, such as the LDL receptor, this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, to recruit them to clathrin-coated pits, 5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, 5-bisphosphate (PtdIns(4, Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	650nm/665nm
Synonyms:	DOC-2
Properties:	ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the DAB2 (Ser24) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	ALEXA FLUOR 647, Alexa Fluor
Gene target:	DAB2 (Ser24)
Short name:	DAB2 (Ser24) Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 647
Alternative name:	ALEXA FLUOR 647, DAB2 (Ser24) (Antibody to)
Alternative technique:	antibodies
Identity:	2662
Gene:	DAB2 | More about : DAB2
Long gene name:	DAB2, clathrin adaptor protein
Synonyms gene name:	disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein) disabled homolog 2, homolog 2 (Drosophila) , mitogen-responsive phosphoprotein, mitogen-responsive phosphoprotein (Drosophila) Dab
Locus:	5p13, 1
Discovery year:	1998-07-29
GenBank acession:	U53446
Entrez gene record:	1601
Pubmed identfication:	8660969 9620555
RefSeq identity:	NM_001343
Havana BLAST/BLAT:	OTTHUMG00000162043

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