DAB2 (Ser24) Antibody, ALEXA FLUOR 350

Catalog number:	bs-11044R-A350 Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	DAB2 (Ser24) Antibody, ALEXA FLUOR 350
Quantity:	100ul
Related search:	dab alexa ser fluor endocytosis involved protein receptor phosphoprotein tgfbeta

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Long name:	ALEXA FLUOR 350 Conjugated, DAB2 (Ser24) Polyclonal Antibody
Also known as:	Anti-DAB2 Ser24 PAb ALEXA FLUOR 350
Category:	Conjugated Primary Antibodies
Conjugated with:	350, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	DAB2 Ser24
Specificity:	This is a highly specific antibody against DAB2 Ser24
Modification:	Phosphorylation
Modification Site:	Ser24
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Subcellular location:	Cytoplasm
Source:	KLH conjugated synthetic phosphopeptide derived from human DAB2 around the phosphorylation site of Ser24 [AP(p-S)KK]
Gene ID Number:	1601
Swiss Prot:	P98082
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	Can bind and assemble clathrin, Can function in clathrin-mediated endocytosis independently of the AP-2 complex, EPS15L1 and ITSN1, Involved in CFTR trafficking to the late endosome, Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2, Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR, Involved in endocytosis of integrin beta-1, Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development, Involved in several receptor-mediated signaling pathways, May activate non-canonical Wnt signaling, May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1), Mediates TFG-beta-stimulated JNK activation, Required for recycling of the TGF-beta receptor, Sequesters LRP6 towards clathrin-mediated endocytosis, and binds simultaneously to phosphatidylinositol 4, leading to inhibition of Wnt/beta-catenin signaling, such as the LDL receptor, this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, to recruit them to clathrin-coated pits, 5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, 5-bisphosphate (PtdIns(4, Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	343nm/442nm
Synonyms:	DOC-2
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	ALEXA FLUOR 350, Alexa Fluor
Gene target:	DAB2 (Ser24)
Short name:	DAB2 (Ser24) Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 350
Alternative name:	ALEXA FLUOR 350, DAB2 (Ser24) (Antibody to)
Alternative technique:	antibodies
Identity:	2662
Gene:	DAB2 | More about : DAB2
Long gene name:	DAB2, clathrin adaptor protein
Synonyms gene name:	disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein) disabled homolog 2, homolog 2 (Drosophila) , mitogen-responsive phosphoprotein, mitogen-responsive phosphoprotein (Drosophila) Dab
Locus:	5p13, 1
Discovery year:	1998-07-29
GenBank acession:	U53446
Entrez gene record:	1601
Pubmed identfication:	8660969 9620555
RefSeq identity:	NM_001343
Havana BLAST/BLAT:	OTTHUMG00000162043

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